Multitasking dynamic contrast enhanced magnetic resonance imaging can accurately differentiate chronic pancreatitis from pancreatic ductal adenocarcinoma.
Multitasking dynamic contrast enhanced magnetic resonance imaging can accurately differentiate chronic pancreatitis from pancreatic ductal adenocarcinoma.
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DOI：
10.3389/fonc.2022.1007134
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发表时间：
2022
影响因子：
4.7
通讯作者：
Li, Debiao
中科院分区：
文献类型：
--
作者：
Wang, Nan;Gaddam, Srinivas;Xie, Yibin;Christodoulou, Anthony G.;Wu, Chaowei;Ma, Sen;Fan, Zhaoyang;Wang, Lixia;Lo, Simon;Hendifar, Andrew E.;Pandol, Stephen J.;Li, Debiao
关键词：
准确区分慢性胰腺炎（CP）和胰腺导管腺癌（PDAC）是一个尚未满足的临床需求领域。在这项研究中，一种新的多任务动态对比增强（DCE）磁共振成像（MRI）技术被用来定量评价胰腺微循环的性质，CP和PDAC和区分它们。多任务DCE技术能够在MRI造影剂通过期间每秒采集一个3D图像，允许定量估计组织的微循环特性，包括血流Fp、血浆体积分数vp、传递常数Ktranss和血管外细胞外体积分数ve。进行受试者工作特征（ROC）分析以区分CP胰腺、PDAC胰腺、正常对照胰腺、PDAC肿瘤、PDAC上游和PDAC下游。比较了定量分析和常规分析的ROC曲线。前瞻性招募了14名PDAC患者、8名CP患者和20名健康受试者。Fp、vp、Ktranss和ve的组合可以区分CP与PDAC胰腺，具有良好的AUC（AUC [95% CI] = 0.821 [0.654 - 0.988]），CP vs正常胰腺，AUC极佳（1.000 [1.000 - 1.000]），PDAC胰腺vs正常胰腺，AUC极佳（1.000 [1.000 - 1.000]），CP与PDAC肿瘤，AUC极佳（1.000 [1.000 - 1.000]），CP与PDAC下游，AUC极佳（0.917 [0.795 - 1.000]），CP与PDAC上游的AUC相当（0.722 [0.465 - 0.980]）。这种定量分析在区分每对中优于常规分析。多任务DCE MRI是一种很有前途的临床工具，能够在CP与PDAC之间进行无偏定量区分。
Accurate differentiation of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is an area of unmet clinical need. In this study, a novel Multitasking dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) technique was used to quantitatively evaluate the microcirculation properties of pancreas in CP and PDAC and differentiate between them. The Multitasking DCE technique was able to acquire one 3D image per second during the passage of MRI contrast agent, allowing the quantitative estimation of microcirculation properties of tissue, including blood flow Fp, plasma volume fraction vp, transfer constant Ktrans, and extravascular extracellular volume fraction ve. Receiver operating characteristic (ROC) analysis was performed to differentiate the CP pancreas, PDAC pancreas, normal control pancreas, PDAC tumor, PDAC upstream, and PDAC downstream. ROCs from quantitative analysis and conventional analysis were compared. Fourteen PDAC patients, 8 CP patients and 20 healthy subjects were prospectively recruited. The combination of Fp, vp, Ktrans, and ve can differentiate CP versus PDAC pancreas with good AUC (AUC [95% CI] = 0.821 [0.654 – 0.988]), CP versus normal pancreas with excellent AUC (1.000 [1.000 – 1.000]), PDAC pancreas versus normal pancreas with excellent AUC (1.000 [1.000 – 1.000]), CP versus PDAC tumor with excellent AUC (1.000 [1.000 – 1.000]), CP versus PDAC downstream with excellent AUC (0.917 [0.795 – 1.000]), and CP versus PDAC upstream with fair AUC (0.722 [0.465 – 0.980]). This quantitative analysis outperformed conventional analysis in differentiation of each pair. Multitasking DCE MRI is a promising clinical tool that is capable of unbiased quantitative differentiation between CP from PDAC.
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影响因子：
3.3
作者：
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通讯作者：
Buckley, David L.
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
4.5
作者：
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Hu, Liang-Hao
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2.9
作者：
Cruz-Monserrate Z;Gumpper K;Kaul S;Badi N;Terhorst S;Dubay K;Lesinski GB;Fisher W;McElhany A;Lara LF;Krishna S;Mace T;Higuita-Castro N;Ortega-Pineda L;Freitas MA;Hinton A;Yadav D;Hart PA;Pandol SJ;Ahmed S;Fatou B;Steen H;Conwell DL;Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer##
通讯作者：
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer##
影响因子：
28.1
作者：
Christodoulou AG;Shaw JL;Nguyen C;Yang Q;Xie Y;Wang N;Li D
通讯作者：
Li D