Gene gain facilitated endosymbiotic evolution of Chlamydiae.
Gene gain facilitated endosymbiotic evolution of Chlamydiae.
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DOI：
10.1038/s41564-022-01284-9
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发表时间：
2023-01
影响因子：
28.3
通讯作者：
中科院分区：
文献类型：
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作者：
衣原体是由专性动物和原生生物内共生体组成的细菌门。然而，其他的浮游菌-疣微菌-衣原体超门的成员主要是自由生活。衣原体如何转变为内共生的生活方式仍然在很大程度上没有解决。在这里，我们重建了浮游菌-疣微菌-衣原体物种关系，并模拟了超门基因组进化。从11，996个基因家族的基因内容重建表明，一个运动和兼性厌氧的最后一个共同的衣原体祖先，已经获得了特征性的内共生体基因。与严格的内共生体中基因组精简的预期相反，我们在衣原体中检测到大量的基因获得。我们发现，在现存的谱系中观察到的能量代谢和有氧作用的分歧出现在衣原体进化的后期。特别是，代谢和有氧基因特征的代谢更多才多艺的原生感染衣原体获得，如呼吸链复合体。我们的研究结果表明，代谢的复杂性可以增加内共生体的进化过程中，增加了一个额外的角度来理解共生体的进化轨迹在整个生命之树。通过水平基因转移获得的大量基因促进了专性细胞内衣原体的进化。
Chlamydiae is a bacterial phylum composed of obligate animal and protist endosymbionts. However, other members of the Planctomycetes–Verrucomicrobia–Chlamydiae superphylum are primarily free living. How Chlamydiae transitioned to an endosymbiotic lifestyle is still largely unresolved. Here we reconstructed Planctomycetes–Verrucomicrobia–Chlamydiae species relationships and modelled superphylum genome evolution. Gene content reconstruction from 11,996 gene families suggests a motile and facultatively anaerobic last common Chlamydiae ancestor that had already gained characteristic endosymbiont genes. Counter to expectations for genome streamlining in strict endosymbionts, we detected substantial gene gain within Chlamydiae. We found that divergence in energy metabolism and aerobiosis observed in extant lineages emerged later during chlamydial evolution. In particular, metabolic and aerobic genes characteristic of the more metabolically versatile protist-infecting chlamydiae were gained, such as respiratory chain complexes. Our results show that metabolic complexity can increase during endosymbiont evolution, adding an additional perspective for understanding symbiont evolutionary trajectories across the tree of life. Extensive gene gain via horizontal gene transfer facilitated the evolution of obligate intracellular Chlamydiae.
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DOI：
10.1038/ismej.2017.95
发表时间：
2017-10
期刊：
The ISME journal
影响因子：
--
作者：
Collingro A;Köstlbacher S;Mussmann M;Stepanauskas R;Hallam SJ;Horn M
通讯作者：
Horn M
影响因子：
14.9
作者：
Blum M;Chang HY;Chuguransky S;Grego T;Kandasaamy S;Mitchell A;Nuka G;Paysan-Lafosse T;Qureshi M;Raj S;Richardson L;Salazar GA;Williams L;Bork P;Bridge A;Gough J;Haft DH;Letunic I;Marchler-Bauer A;Mi H;Natale DA;Necci M;Orengo CA;Pandurangan AP;Rivoire C;Sigrist CJA;Sillitoe I;Thanki N;Thomas PD;Tosatto SCE;Wu CH;Bateman A;Finn RD
通讯作者：
Finn RD
影响因子：
14.9
作者：
NCBI Resource Coordinators
通讯作者：
NCBI Resource Coordinators
影响因子：
5.2
作者：
Degli Esposti, Mauro;Mentel, Marek;Sousa, Filipa L.
通讯作者：
Sousa, Filipa L.
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS