A Vaccine for Canine Rocky Mountain Spotted Fever: An Unmet One Health Need.
A Vaccine for Canine Rocky Mountain Spotted Fever: An Unmet One Health Need.
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DOI：
10.3390/vaccines10101626
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发表时间：
2022-09-28
期刊：
影响因子：
7.8
通讯作者：
Narra HP
中科院分区：
文献类型：
--
作者：
Walker DH;Blanton LS;Laroche M;Fang R;Narra HP
与犬蜱维持周期相关的危及生命的落基山斑疹热在人类和狗中的爆发构成了一个重要的健康机会。这个问题的现实在墨西哥、巴西、哥伦比亚和亚利桑那州的美洲原住民部落地区都有明显的表现。棕色犬蜱，广义血红扇头蜱，从菌血症犬获得立克次体，并可将细菌跨宿主维持至下一蜱阶段。随后的成年蜱可以将感染传播给新的宿主，如豚鼠模型所示。这些棕色狗蜱通过许多代保持斑点热群立克次体，因此既作为媒介又作为水库。含全灭活R.立克次氏体不能激发足够的免疫力。对立克次体亚单位抗原的研究表明，构象保留的外膜自转运蛋白A和B是主要的疫苗候选者。随着基因敲除方法应用于这些专性细胞内病原体，潜在安全有效的减毒活疫苗的可能性才开始探索。
Outbreaks of life-threatening Rocky Mountain spotted fever in humans and dogs associated with a canine-tick maintenance cycle constitute an important One Health opportunity. The reality of the problem has been observed strikingly in Mexico, Brazil, Colombia, and Native American tribal lands in Arizona. The brown dog tick, Rhipicephalus sanguineus sensu lato, acquires the rickettsia from bacteremic dogs and can maintain the bacterium transtadially to the next tick stage. The subsequent adult tick can then transmit infection to a new host, as shown by guinea pig models. These brown dog ticks maintain spotted fever group rickettsiae transovarially through many generations, thus serving as both vector and reservoir. Vaccine containing whole-killed R. rickettsii does not stimulate sufficient immunity. Studies of Rickettsia subunit antigens have demonstrated that conformationally preserved outer-membrane autotransporter proteins A and B are the leading vaccine candidates. The possibility of a potentially safe and effective live attenuated vaccine has only begun to be explored as gene knockout methods are applied to these obligately intracellular pathogens.
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影响因子：
2.1
作者：
Alkmim, Matheus Araujo de;Ferreira, Lorena Lopes;Silveira, Julia Angelica Goncalves da
通讯作者：
Silveira, Julia Angelica Goncalves da
影响因子：
11.8
作者：
ARCHIBALD, LK;SEXTON, DJ
通讯作者：
SEXTON, DJ
影响因子：
3.3
作者：
Backus, Laura H.;Perez, Andres M. Lopez;Foley, Janet E.
通讯作者：
Foley, Janet E.
影响因子：
2.2
作者：
Coimbra-Dores, Maria Joao;Nunes, Telmo;Rosa, Fernanda
通讯作者：
Rosa, Fernanda
影响因子：
3.4
作者：
Cardwell MM;Martinez JJ
通讯作者：
Martinez JJ