Feeling left out: depressed adolescents may atypically recruit emotional salience and regulation networks during social exclusion.
Feeling left out: depressed adolescents may atypically recruit emotional salience and regulation networks during social exclusion.
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DOI：
10.1093/scan/nsy055
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发表时间：
2018-09-05
影响因子：
4.2
通讯作者：
Quevedo K
中科院分区：
文献类型：
--
作者：
Jankowski KF;Batres J;Scott H;Smyda G;Pfeifer JH;Quevedo K
抑郁症与负性注意和归因偏见、情绪反应和调节不良有关，对自我评价和人际关系产生不利影响。使用功能磁共振成像，我们研究了这些损伤的神经基质。我们比较了126名临床抑郁和健康青少年（11-17岁）在使用赛博球进行社会排斥（排斥bb0包容）时的神经活动。结果显示，左脑岛前部/额下回和左颞中回之间存在显著的交互作用。脑岛高反应性与抑郁青少年的同伴排斥有关，而与健康青少年的同伴包容有关。此外，健康青少年在同伴排斥期间的颞外侧活动更大。在独立分组内的互补效应大小分析提供了收敛的证据，并强调了亚一般/腹侧前扣带皮层和涉及情绪调节的外侧前额叶、外侧颞叶和外侧顶叶区域的中大型效应。抑郁神经模式与消极的自我认知和消极的信息处理偏差有关。这些发现提示抑郁症认知偏差的神经机制，反映在情绪高反应和对负面社会评价信息的不适应调节/重新评价上。本研究进一步支持了社会威胁处理背后的突出性和中央执行网络功能障碍，特别强调了前岛是青少年抑郁症的一个关键紊乱区域。
Depression is associated with negative attention and attribution biases and maladaptive emotion responsivity and regulation, which adversely impact self-evaluations and interpersonal relationships. Using functional magnetic resonance imaging, we investigated the neural substrates of these impairments. We compared neural activity recruited by 126 clinically depressed and healthy adolescents (ages 11–17 years) during social exclusion (Exclusion > Inclusion) using Cyberball. Results revealed significant interaction effects within left anterior insula (AI)/inferior frontal gyrus and left middle temporal gyrus. Insula hyperresponsivity was associated with peer exclusion for depressed adolescents but peer inclusion for healthy adolescents. In additional, healthy adolescents recruited greater lateral temporal activity during peer exclusion. Complementary effect size analyses within independent parcellations offered converging evidence, as well as highlighted medium-to-large effects within subgenual/ventral anterior cingulate cortex and lateral prefrontal, lateral temporal and lateral parietal regions implicated in emotion regulation. Depressogenic neural patterns were associated with negative self-perceptions and negative information processing biases. These findings suggest a neural mechanism underlying cognitive biases in depression, as reflected by emotional hyperresponsivity and maladaptive regulation/reappraisal of negative social evaluative information. This study lends further support for salience and central executive network dysfunction underlying social threat processing, and in particular, highlights the anterior insula as a key region of disturbance in adolescent depression.
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