High prevalence of sexually transmitted infections and risk factors among HIV-positive individuals in Yunnan, China.
High prevalence of sexually transmitted infections and risk factors among HIV-positive individuals in Yunnan, China.
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中国云南省HIV阳性人群性传播感染高患病率及危险因素
DOI：
10.1186/s40001-022-00635-w
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发表时间：
2022-01-13
影响因子：
4.2
通讯作者：
Lu L
中科院分区：
文献类型：
--
作者：
Tu W;Li YY;Kuang YQ;Xie RH;Dong XQ;Zhang D;Ma YL;Zhang WY;Lu L
云南是中国艾滋病毒感染率最高的地区。其他可治疗的性传播感染与艾滋病毒传播加速和抗逆转录病毒治疗效果差有关，但只能通过综合征算法进行诊断。方法：我们招募了406名hiv阳性参与者进行横断面研究（204名未接受ART治疗，202名接受ART治疗）。采集血样和初空尿样。采用实时聚合酶链反应法诊断沙眼衣原体（CT）、淋病奈瑟菌（NG）和生殖支原体（MG）。梅毒和单纯疱疹病毒2型（HSV-2）检测也进行。结果406名参与者中，未接受ART治疗的性传播感染总体患病率为47.0%，接受ART治疗的性传播感染总体患病率为45.1%，接受ART治疗的性传播感染总体患病率为49.0%。活动性梅毒、HSV-2、CT、NG和MG的检测频率分别为11.6%（11.8%比11.4%）、33.2%（29.4%比37.1%）、3.2%（3.4%比3.0%）、2.0%（3.4%比0.5%）和4.7%（6.4%比3.0%）。两组中首次接受抗逆转录病毒治疗的患者的多重感染百分比为10.8%(22/204)，接受抗逆转录病毒治疗的患者的多重感染百分比为9.9%（20/202）。女性、年龄在18至35岁之间、曾经注射毒品、同性恋或双性恋、HIV/HBV合并感染以及未接受抗逆转录病毒治疗被确定为危险因素。自我报告无症状的患者并没有被排除患有实验室诊断的性传播感染。结论性病患病率为47.0%(45.1%比49.0%)，其中2型单纯疱疹病毒、梅毒和MG是hiv感染者中最常见的性病。我们发现MG在未接受art治疗的个体中患病率很高（6.4%）。艾滋病毒阳性个体往往忽视或隐瞒其生殖道不适；因此，我们建议在艾滋病毒感染者中加强性传播感染联合筛查和治疗服务，无论他们是否描述生殖道不适。
BackgroundYunnan has the highest rates of HIV in China. Other treatable sexually transmitted infections (STIs) are associated with accelerated HIV transmission and poor ART outcomes, but are only diagnosed by syndromic algorithms.MethodsWe recruited 406 HIV-positive participants for a cross-sectional study (204 ART-naive and 202 receiving ART). Blood samples and first-voided urine samples were collected. Real-time polymerase chain reaction methods were used for diagnosingChlamydia trachomatis(CT),Neisseria gonorrhea(NG) andMycoplasma genitalium(MG).Syphilis and herpes simplex virus type 2 (HSV-2) tests were also performed.ResultsAmong the 406 participants, the overall prevalence of STIs was 47.0% and 45.1% in ART-naive individuals and 49.0% in individuals receiving ART, respectively. The testing frequencies were 11.6% (11.8% vs. 11.4%), 33.2% (29.4% vs. 37.1%), 3.2% (3.4% vs. 3.0%), 2.0% (3.4% vs. 0.5%) and 4.7% (6.4% vs. 3.0%) for active syphilis, HSV-2, CT, NG and MG, respectively. The percentage of multiple infections in both groups was 10.8% (22/204) in ART-naive participants and 9.9% (20/202) in participants receiving ART. Female sex, an age between 18 and 35 years, ever injecting drugs, homosexual or bisexual status, HIV/HBV coinfection, and not receiving ART were identified as risk factors. Self-reported asymptomatic patients were not eliminated from having a laboratory-diagnosed STI.ConclusionsThe STI prevalence was 47.0% (45.1% vs. 49.0%), and HSV-2, syphilis and MG were the most common STIs in HIV-infected individuals. We found a high prevalence (6.4%) of MG in ART-naive individuals. HIV-positive individuals tend to neglect or hide their genital tract discomfort; thus, we suggest strengthening STI joint screening and treatment services among HIV-infected individuals regardless of whether they describe genital tract discomfort.
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影响因子：
1.4
作者：
Duffus, WA;Mermin, J;Downing, R
通讯作者：
Downing, R
影响因子：
2.2
作者：
Hu, Qing-hai;Xu, Jun-jie;Shang, Hong
通讯作者：
Shang, Hong
影响因子：
3.1
作者：
Footman, Alison;Dionne-Odom, Jodie;Van der Pol, Barbara
通讯作者：
Van der Pol, Barbara
DOI：
10.3390/ijerph16091507
发表时间：
2019-05-01
影响因子：
--
作者：
Chen, Lin;Yang, Jiezhe;Pan, Xiaohong
通讯作者：
Pan, Xiaohong
影响因子：
7.3
作者：
Crisci, Elisa;Svanberg, Cecilia;Larsson, Marie
通讯作者：
Larsson, Marie