Urban-rural disparity of breast cancer and socioeconomic risk factors in China.
Urban-rural disparity of breast cancer and socioeconomic risk factors in China.
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DOI：
10.1371/journal.pone.0117572
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Christakos G
中科院分区：
文献类型：
--
作者：
Fei X;Wu J;Kong Z;Christakos G
乳腺癌是全世界最常诊断的癌症之一。这项工作的主要目的是研究中国城市与农村地区女性乳腺癌的差异及其与社会经济因素的关系。乳腺癌发病率数据来自中国癌症登记年度报告（2005-2009）。本研究考虑的十个社会经济因素来自2000年全国人口普查和中国市/县统计年鉴。学生 T 检验用于评估城市与农村地区女性乳腺癌和社会经济因素的差异。采用皮尔逊相关和普通最小二乘（OLS）模型来分析社会经济因素与癌症发病率之间的关系。研究发现，城市乳腺癌发病率明显高于农村。此外，在城市地区，乳腺癌发病率保持相对稳定，而在农村地区，其年变化百分比（APC）为8.55。在考虑的各种社会经济因素中，乳腺癌发病率与人口密度、非农业人口比重、第二产业产值呈现较高的正相关性。另一方面，发病率与从事第一产业的人口比例呈负相关。总体而言，据观察，较高的社会经济地位将导致中国较高的乳腺癌发病率。在研究乳腺癌病因时，应特别关注环境污染物，尤其是工业活动中产生的内分泌干扰物。最后，本研究的结果强烈建议高度重视为中国女性制定系统的全国性乳腺癌筛查计划；如果有足够的参与，乳房X光检查可以大大降低妇女的死亡率。
Breast cancer is one of the most commonly diagnosed cancers worldwide. The primary aim of this work is the study of breast cancer disparity among Chinese women in urban vs. rural regions and its associations with socioeconomic factors. Data on breast cancer incidence were obtained from the Chinese cancer registry annual report (2005–2009). The ten socioeconomic factors considered in this study were obtained from the national population 2000 census and the Chinese city/county statistical yearbooks. Student’s T test was used to assess disparities of female breast cancer and socioeconomic factors in urban vs. rural regions. Pearson correlation and ordinary least squares (OLS) models were employed to analyze the relationships between socioeconomic factors and cancer incidence. It was found that the breast cancer incidence was significantly higher in urban than in rural regions. Moreover, in urban regions, breast cancer incidence remained relatively stable, whereas in rural regions it displayed an annual percentage change (APC) of 8.55. Among the various socioeconomic factors considered, breast cancer incidence exhibited higher positive correlations with population density, percentage of non-agriculture population, and second industry output. On the other hand, the incidence was negatively correlated with the percentage of population employed in primary industry. Overall, it was observed that higher socioeconomic status would lead to a higher breast cancer incidence in China. When studying breast cancer etiology, special attention should be paid to environmental pollutants, especially endocrine disruptors produced during industrial activities. Lastly, the present work’s findings strongly recommend giving high priority to the development of a systematic nationwide breast cancer screening program for women in China; with sufficient participation, mammography screening can considerably reduce mortality among women.
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