Melatonin improves quality and longevity of chronic neural recording.
Melatonin improves quality and longevity of chronic neural recording.
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DOI：
10.1016/j.biomaterials.2018.07.026
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发表时间：
2018-10
期刊：
影响因子：
14
通讯作者：
Cui XT
中科院分区：
文献类型：
--
作者：
Golabchi A;Wu B;Li X;Carlisle DL;Kozai TDY;Friedlander RM;Cui XT
可植入神经电极的慢性功能受到炎症性脑组织反应的阻碍，包括小胶质细胞激活、胶质瘢痕形成和神经元丢失。褪黑素(MT)通过抑制caspase−1、−3和−9的激活和线粒体细胞色素c的释放，减轻氧化应激和神经炎症，在治疗中枢神经系统损伤和退行性变方面显示出显著的神经保护和神经修复作用。本研究观察了MT对植入小鼠视皮层微电极16周的神经记录质量和寿命的影响。急性(植入前3d和植入后14d)和慢性(植入前3d和植入后16周)暴露组每日腹腔注射MT(30 mg/kg)。在前4周，两个MT组的单位产量(SU)、信噪比(SNR)和波幅均显著高于赋形剂对照组。然而，植入4周后，急性治疗组的SU产量下降到与对照组相同的水平，而慢性治疗组的SU产量显著高于急性(5-16周)和对照组(0-16周)。组织学研究显示，与对照组和急性组相比，慢性组在16周时植入电极周围的神经元存活率显著增加，神经元凋亡率显著减少，这与氧化应激减少和促再生精氨酸酶-1阳性小胶质细胞的数量增加有关。这些结果证明了MT治疗在维持高质量的电极-组织界面方面的强大作用，并提示MT可能通过其抗凋亡、抗炎和抗氧化特性来促进神经保护。本研究证实了在慢性微电极脑植入中，褪黑素治疗在抑制持续性炎症和神经元丢失以及维持高质量神经记录方面的有效作用。
The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase−1, −3 and −9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation. This study examined the effect of MT administration on the quality and longevity of neural recording from implanted microelectrode in the visual cortex of mice for 16 weeks. MT (30 mg/kg) was administered via daily intraperitoneal injection for acute (3 days before and 14 days post implantation) and chronic (3 days before and 16 weeks post implantation) exposures. During the first 4 weeks, both MT groups showed significantly higher single-unit (SU) yield, signal-to-noise ratio (SNR), and amplitude compared to the vehicle control group. However, after 4 weeks of implantation, the SU yield of the acute treatment group dropped to the same level as control group, while the chronic treatment group maintained significantly higher SU yield compared to both acute (week 5–16) and control (week 0–16) mice. Histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. These results demonstrate the potent effect of MT treatment in maintaining a high quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory and anti-oxidative properties. This study demonstrated the potent effect of melatonin treatment in inhibiting persistent inflammation and neuronal loss, as well as maintaining high quality neural recording in chronic microelectrode brain implantation.
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影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
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影响因子：
5.6
作者：
Carrillo-Vico A;Lardone PJ;Alvarez-Sánchez N;Rodríguez-Rodríguez A;Guerrero JM
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作者：
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通讯作者：
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影响因子：
20.3
作者：
Deng, Wu-Guo;Tang, Shao-Tzu;Wu, Kenneth K.
通讯作者：
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影响因子：
105.7
作者：
Buscemi, N;Vandermeer, B;Baker, G
通讯作者：
Baker, G