Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure-Activity Relationships.
Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure-Activity Relationships.
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DOI：
10.3390/ph14050428
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发表时间：
2021-05-02
期刊：
影响因子：
--
通讯作者：
Tembu VJ
中科院分区：
文献类型：
--
作者：
Magozwi DK;Dinala M;Mokwana N;Siwe-Noundou X;Krause RWM;Sonopo M;McGaw LJ;Augustyn WA;Tembu VJ
大戟属植物广泛分布于南美洲、亚洲和非洲的温带、热带和亚热带地区，并有阿育吠陀、中国和马来民族医学记录。本文综述了2000-2020年大戟属黄酮类化合物的分离、发生、植物化学、生物学特性、治疗潜力和构效关系，同时确定了未来研究的潜在领域，旨在从这些植物中开发新的治疗药物。结果表明，提取物和分离的黄酮类化合物具有抗癌，抗增殖，抗疟疾，抗菌，抗蛇毒，抗炎，抗肝炎和抗氧化剂的性质，并具有不同的作用机制对癌细胞。在所调查的物种中，迄今已分离出80多种不同类型的黄酮类化合物。大部分分离的黄酮类化合物是黄酮醇，包括简单的O-取代模式，C-甲基化和异戊二烯化。其他的具有糖苷、糖苷键和在C-3或C-7处连接的碳水化合物，并且被指定为d-葡萄糖、l-鼠李糖或葡糖鼠李糖。构效关系研究表明，C-3或C-7位羟基的甲基化会降低活性，而糖基化则会失去活性，母体骨架结构对保持活性至关重要。因此，这些成分可以为开发新的基于大戟的治疗剂提供潜在的替代支架。
Plants of the genus Euphorbia are widely distributed across temperate, tropical and subtropical regions of South America, Asia and Africa with established Ayurvedic, Chinese and Malay ethnomedical records. The present review reports the isolation, occurrence, phytochemistry, biological properties, therapeutic potential and structure–activity relationship of Euphorbia flavonoids for the period covering 2000–2020, while identifying potential areas for future studies aimed at development of new therapeutic agents from these plants. The findings suggest that the extracts and isolated flavonoids possess anticancer, antiproliferative, antimalarial, antibacterial, anti-venom, anti-inflammatory, anti-hepatitis and antioxidant properties and have different mechanisms of action against cancer cells. Of the investigated species, over 80 different types of flavonoids have been isolated to date. Most of the isolated flavonoids were flavonols and comprised simple O-substitution patterns, C-methylation and prenylation. Others had a glycoside, glycosidic linkages and a carbohydrate attached at either C-3 or C-7, and were designated as d-glucose, l-rhamnose or glucorhamnose. The structure–activity relationship studies showed that methylation of the hydroxyl groups on C-3 or C-7 reduces the activities while glycosylation loses the activity and that the parent skeletal structure is essential in retaining the activity. These constituents can therefore offer potential alternative scaffolds towards development of new Euphorbia-based therapeutic agents.
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影响因子：
5.4
作者：
Cushnie, TPT;Lamb, AJ
通讯作者：
Lamb, AJ
DOI：
10.3390/plants10010008
发表时间：
2020-12-23
期刊：
Plants (Basel, Switzerland)
影响因子：
--
作者：
Rojas R;Tafolla-Arellano JC;Martínez-Ávila GCG
通讯作者：
Martínez-Ávila GCG
影响因子：
3.3
作者：
Ajayi, E. I. O.;Adeleke, M. A.;Adeyemi, A. A.
通讯作者：
Adeyemi, A. A.
影响因子：
6
作者：
Al-Yousef, Hanan M.;Alqahtani, Ali S.;Hassan, Hanaa M.
通讯作者：
Hassan, Hanaa M.
影响因子：
4.6
作者：
Belchor, Mariana Novo;Gaeta, Henrique Hessel;Toyama, Marcos Hikari
通讯作者：
Toyama, Marcos Hikari