Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
Dissociable neural systems for timing: evidence from subjects with basal ganglia lesions.
复制标题
DOI：
10.1371/journal.pone.0010324
复制
发表时间：
2010-04-23
期刊：
影响因子：
3.7
通讯作者：
Chatterjee A
中科院分区：
文献类型：
--
作者：
Coslett HB;Wiener M;Chatterjee A
时间的神经基础仍然知之甚少。尽管争议仍在继续，但许多证据，包括对动物的研究，对人类的功能成像研究，以及对人和动物的损伤研究，都表明基底节对时间处理非常重要。我们报告了来自两个由双侧基底节损伤引起的致残神经缺陷的受试者的广泛计时任务的数据。两名受试者在评估时间估计任务、复制任务和生产任务上都表现良好。此外，一名受试者在需要比较时间间隔从毫秒到秒的心理物理任务中表现正常；另一名受试者在300ms标准的心理物理任务中表现不正常，但在600ms、2000ms和8000ms标准下表现良好。这两名受试者在一项要求他们保持有节奏的敲击的同步节奏产生任务中表现不佳。由于对大脑损伤受试者的研究允许对大脑结构的必要性进行强有力的推断，这些数据表明，基底节对于人类许多亚秒或超秒的计时操作并不关键，但对于构成运动产生的计时程序是必要的。这种解离表明，可以采用不同的和可解离的过程来测量时间间隔。关于时间的神经基础的研究结果的不一致可能反映了灵活实施的多个时间处理例程的可用性，以响应任务需求。
The neural basis of timing remains poorly understood. Although controversy persists, many lines of evidence, including studies in animals, functional imaging studies in humans and lesion studies in humans and animals suggest that the basal ganglia are important for temporal processing. We report data from a wide range of timing tasks from two subjects with disabling neurologic deficits caused by bilateral lesions of the basal ganglia. Both subjects perform well on tasks assessing time estimation, reproduction and production tasks. Additionally, one subject performed normally on psychophysical tasks requiring the comparison of time intervals ranging from milliseconds to seconds; the second subject performed abnormally on the psychophysical task with a 300ms standard but did well with 600ms, 2000ms and 8000ms standards. Both subjects performed poorly on an isochronous rhythm production task on which they are required to maintain rhythmic tapping. As studies of subjects with brain lesions permit strong inferences regarding the necessity of brain structures, these data demonstrate that the basal ganglia are not crucial for many sub- or supra-second timing operations in humans but are needed for the timing procedures that underlie the production of movements. This dissociation suggests that distinct and dissociable processes may be employed to measure time intervals. Inconsistencies in findings regarding the neural basis of timing may reflect the availability of multiple temporal processing routines that are flexibly implemented in response to task demands.
登录
查看更多内容
影响因子：
4.1
作者：
Freeman, J S;Cody, F W;Snowden, J S
通讯作者：
Snowden, J S
影响因子：
2.6
作者：
Lewis, PA;Wing, AM;Miall, RC
通讯作者：
Miall, RC
影响因子：
3.2
作者：
Ivry, R B;Keele, S W
通讯作者：
Keele, S W
影响因子：
2
作者：
Chiba, Atsushi;Oshio, Ken-ichi;Inase, Masahiko
通讯作者：
Inase, Masahiko
影响因子：
2.6
作者：
Gooch CM;Wiener M;Wencil EB;Coslett HB
通讯作者：
Coslett HB