Lesions of the head direction cell system impair direction discrimination.
Lesions of the head direction cell system impair direction discrimination.
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头部方向细胞系统的损伤会损害方向辨别能力。
DOI：
10.1037/bne0000341
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发表时间：
2019
影响因子：
1.9
通讯作者：
Smith AE
中科院分区：
文献类型：
--
作者：
Smith AE
以前的研究结果表明，方向信息的头部方向细胞电路可能会通知海马位置细胞发射时，动物面临着视觉上相同的环境。为了研究这些信息是否对空间行为也是必不可少的，我们测试了成年雄性Lister Hooded大鼠，这些大鼠接受了双侧外侧乳头状核（LMN）病变或假病变，在以60度间隔排列的隔间中进行了四向条件气味位置辨别。我们发现，与假手术组相比，LMN损伤组中能够学习任务的大鼠显著减少。我们还发现，行为障碍的程度是高度相关的，在LMN的组织损失的程度所造成的损害。LMN病变的动物在T迷宫中的非匹配样本任务中也受到损害，损害的程度同样取决于病变的程度。在气味定位和T-迷宫任务的性能没有受到影响的组织损失，在内侧乳头核。总之，这些结果表明，LMN，在头部方向电路中的关键节点，是解决空间任务，需要一个方向歧视的关键。
Previous results suggest that directional information from the head direction cell circuit may inform hippocampal place cell firing when an animal is confronted with visually identical environments. To investigate whether such information might also be essential for spatial behavior, we tested adult, male Lister Hooded rats that had received either bilateral lateral mammillary nuclei (LMN) lesions or sham lesions on a four-way, conditional odor-location discrimination in compartments arranged at 60 to one another. We found that significantly fewer rats in the LMN lesion group were able to learn the task compared to the Sham group. We also found that the extent of the behavioral impairment was highly correlated with the degree of tissue loss in the LMN resulting from the lesion. Animals with LMN lesions were also impaired in a nonmatching-to-sample task in a T maze, and the extent of impairment likewise depended on the extent of the lesion. Performance in the odor-location and T-maze tasks was not affected by tissue loss in the medial mammillary nuclei. Together, these results indicate that the LMN, a key node in the head direction circuit, is critical for solving a spatial task that requires a directional discrimination.
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DOI：
10.1016/0163-1047(92)90629-i
发表时间：
1992-03
期刊：
Behavioral and neural biology
影响因子：
--
作者：
J. Taube;J. Kesslak;C. Cotman
通讯作者：
J. Taube;J. Kesslak;C. Cotman
与外侧乳头核双侧病变相关的短暂空间缺陷
影响因子：
3.4
作者：
S. Vann
通讯作者：
S. Vann
影响因子：
16.2
作者：
Blair, HT;Cho, JW;Sharp, PE
通讯作者：
Sharp, PE
影响因子：
3.8
作者：
Gonzalo-Ruiz, A;Morte, L;Sanz, JM
通讯作者：
Sanz, JM
影响因子：
2.7
作者：
Vann SD
通讯作者：
Vann SD