Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis.
Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis.
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DOI：
10.1016/j.rmed.2012.10.018
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发表时间：
2013-02
影响因子：
4.3
通讯作者：
Collard, Harold R.
中科院分区：
文献类型：
--
作者：
Lee, Joyce S.;Kim, Eunice J.;Lynch, Kara L.;Elicker, Brett;Ryerson, Christopher J.;Katsumoto, Tamiko R.;Shum, Anthony K.;Wolters, Paul J.;Cerri, Stefania;Richeldi, Luca;Jones, Kirk D.;King, Talmadge E., Jr.;Collard, Harold R.
背景循环自身抗体在特发性肺纤维化中的临床意义尚不清楚。本研究的目的是确定循环自身抗体在特发性肺纤维化中的频率和临床意义。方法我们在一组特发性肺纤维化患者(n=67)中检测了与结缔组织病或血管炎相关的广泛的自身抗体(包括类风湿因子、抗环瓜氨酸肽和免疫荧光法的抗核抗体)。比较特发性肺纤维化患者和健康对照组(n=52)循环自身抗体的患病率。比较有无循环自身抗体的患者的临床特点，分析自身抗体阳性与无移植生存时间的关系。结果自身抗体阳性的IPF患者有22%，健康对照组有21%。在特发性肺纤维化患者和健康对照组之间发现的自身抗体类型没有差异。在特发性肺纤维化患者中，有无循环自身抗体的患者在临床特征上没有显著差异。经校正分析，循环自身抗体的存在与较长的无移植生存时间相关，但其意义因使用的统计模型而异(HR 0.22~0.47，p值0.02~0.17)。结论特发性肺纤维化患者循环自身抗体的出现频率与健康对照组相比没有差异，但可能与较长的生存期有关。
BACKGROUNDThe clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis is unclear. The objective of this study was to determine the frequency and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis.METHODSWe measured an extensive panel of autoantibodies (including rheumatoid factor, anti-cyclic citrullinated peptide, and anti-nuclear antibodies by immunofluorescence) associated with connective tissue disease or vasculitis in a cohort of well-characterized patients with idiopathic pulmonary fibrosis (n = 67). The prevalence of circulating autoantibodies was compared between idiopathic pulmonary fibrosis patients and healthy controls (n = 52). We compared the clinical characteristics of patients with and without circulating autoantibodies, and analyzed the relationship between autoantibody positivity and transplant-free survival time.RESULTSPositive autoantibodies were found in 22% of patients with IPF and 21% of healthy controls. There were no differences in the types of autoantibodies found between patients with idiopathic pulmonary fibrosis and healthy controls. Among patients with idiopathic pulmonary fibrosis, there were no significant differences in clinical characteristics between those with and without circulating autoantibodies. The presence of circulating autoantibodies was associated with longer transplant-free survival time on adjusted analysis, however the significance varied depending on which statistical model was used (HR 0.22–0.47, p value 0.02–0.17).CONCLUSIONSThe frequency of circulating autoantibodies in patients with idiopathic pulmonary fibrosis is no different compared to healthy controls, but may be associated with longer survival.
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影响因子：
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