Aquaporins in Immune Cells and Inflammation: New Targets for Drug Development.
Aquaporins in Immune Cells and Inflammation: New Targets for Drug Development.
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DOI：
10.3390/ijms22041845
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发表时间：
2021-02-12
影响因子：
5.6
通讯作者：
Soveral G
中科院分区：
文献类型：
--
作者：
da Silva IV;Soveral G
哺乳动物的免疫系统通过各种免疫细胞相互作用的机制来感知外来抗原，最终导致炎症消退和组织清除。免疫细胞的通信能力(通过趋化因子)以及为迁移、吞噬或抗原摄取而改变形状的能力主要由关键蛋白支持，如水通道蛋白(AQPs)，它调节水液的动态平衡和体积变化。水通道蛋白是促进水和不带电荷的小分子(如甘油或过氧化氢)通过膜扩散的蛋白质通道。许多AQP亚型在炎症条件下上调，被认为是免疫细胞迁移和生存所必需的。本综述更新了AQP参与免疫和炎症过程的信息，强调了它们作为关键参与者和药物发现的有希望的靶标的作用。
The mammalian immune system senses foreign antigens by mechanisms that involve the interplay of various kinds of immune cells, culminating in inflammation resolution and tissue clearance. The ability of the immune cells to communicate (via chemokines) and to shift shape for migration, phagocytosis or antigen uptake is mainly supported by critical proteins such as aquaporins (AQPs) that regulate water fluid homeostasis and volume changes. AQPs are protein channels that facilitate water and small uncharged molecules’ (such as glycerol or hydrogen peroxide) diffusion through membranes. A number of AQP isoforms were found upregulated in inflammatory conditions and are considered essential for the migration and survival of immune cells. The present review updates information on AQPs’ involvement in immunity and inflammatory processes, highlighting their role as crucial players and promising targets for drug discovery.
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