Inhibition of neutrophil superoxide formation by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and inhibitor of protein kinase-C.
Inhibition of neutrophil superoxide formation by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and inhibitor of protein kinase-C.
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1-(5-异喹啉磺酰基)-2-甲基哌嗪 (H-7) 和蛋白激酶-C 抑制剂抑制中性粒细胞超氧化物形成。
DOI：
10.1016/0006-2952(86)90778-1
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发表时间：
1986
影响因子：
5.8
通讯作者：
S. Minakami
中科院分区：
文献类型：
--
作者：
I. Fujita;K. Takeshige;S. Minakami
Superoxide formation of human neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA),N-formyl-methionyl-leucyl-phenylalanine, or calcium ionophore A23187 was inhibited by pretreatment of the cells with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase-C, but was not inhibited byN-(2-guanidinoethyl)-5-isoquinolinesulfonamide which has a less inhibitory effect on the protein kinase-C. H-7 also inhibited superoxide formation of PMA-activated cytoplasts, which lack nuclei and granules. The phosphorylation of proteins induced by PMA in the cytoplasts as well as the intact neutrophils was also inhibited by preincubation with H-7. Among several phosphoproteins affected by H-7, one protein with a molecular weight of 19,000 (pI= 4.9) was inhibited markedly.N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide did not inhibit the phosphorylation of proteins induced by PMA. These findings support the possibility that the protein kinase-C is involved in the activation process of superoxide formation.
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中性粒细胞释放超氧化物：佛波酯和钙离子载体的协同作用。
DOI：
10.1016/s0006-291x(84)80095-9
发表时间：
1984
影响因子：
3.1
作者：
Robinson,JM;Badwey,JA;Karnovsky,ML;Karnovsky,MJ
通讯作者：
Karnovsky,MJ
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DOI：
10.1016/0304-4165(83)90133-2
发表时间：
1983
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Huang,CK;HillJr,JM;Bormann,BJ;Mackin,WM;Becker,EL
通讯作者：
Becker,EL
静止和激活的人类中性粒细胞对胞质蛋白的磷酸化。
影响因子：
20.3
作者：
Andrews,PC;Babior,BM
通讯作者：
Babior,BM
佛波醇 12-肉豆蔻酸酯 13-乙酸酯及其类似物 4α-佛波醇 12,13-二癸酸酯对兔中性粒细胞中蛋白质磷酸化和溶酶体酶释放的影响。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
White,JR;Huang,CK;HillJr,JM;Naccache,PH;Becker,EL;Sha'afi,RI
通讯作者：
Sha'afi,RI
人中性粒细胞中磷脂敏感的 Ca2 依赖性蛋白激酶及其底物。
DOI：
10.1016/0006-291x(83)91376-1
发表时间：
1983
影响因子：
3.1
作者：
Helfman,DM;Appelbaum,BD;Vogler,WR;Kuo,JF
通讯作者：
Kuo,JF