Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups.
Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups.
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DOI：
10.1371/journal.pone.0098630
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Small GW
中科院分区：
文献类型：
--
作者：
Chen ST;Siddarth P;Ercoli LM;Merrill DA;Torres-Gil F;Small GW
以前的研究已经确定了老年人阿尔茨海默病（AD）的可改变的风险因素。研究局限于这些风险因素与主观记忆障碍（SMI）之间的潜在联系，后者可能先于AD和其他痴呆症。检查这些潜在的关系可能有助于识别那些在干预可能延迟或防止进一步记忆问题的阶段有AD风险的人。本研究的目的是确定AD的危险因素是否与不同年龄组的SMI相关。训练有素的采访者对18，614名美国受访者的代表性社区样本进行了每日电话调查（Gallup-Healthways），其中包括4，425名年轻人（18至39岁）、6，365名中年人（40至59岁）和7，824名老年人（60至99岁）成年人。调查人员收集了人口统计学、生活方式和医疗信息方面的数据。研究人员检查了受教育程度低、吸烟、高血压、糖尿病、运动量少、肥胖和抑郁以及它们之间的相互作用与重度精神障碍的关系。加权逻辑回归和卡方检验用于计算SMI与各危险因素的比值比和置信区间以及各年龄组的成对相互作用。在所有三个年龄组中，抑郁、教育程度低、运动量少和高血压与SMI显著相关。风险因素之间的几种相互作用在年轻和中年成人中是显着的，并影响他们与SMI的关联。SMI的发生率随着年龄和危险因素的增加而增加。只有一个风险因素，患SMI的几率就会显著增加。这些结果表明，AD的可改变的风险因素也与SMI相关，这表明这些关系发生在广泛的年龄范围内，并可能有针对性地减轻进一步的记忆问题。是否修改这些危险因素减少SMI和AD和其他痴呆症的最终发病率在以后的生活中仍然有待确定。
Previous research has identified modifiable risk factors for Alzheimer's disease (AD) in older adults. Research is limited on the potential link between these risk factors and subjective memory impairment (SMI), which may precede AD and other dementias. Examination of these potential relationships may help identify those at risk for AD at a stage when interventions may delay or prevent further memory problems. The objective of this study was to determine whether risk factors for AD are associated with SMI among different age groups. Trained interviewers conducted daily telephone surveys (Gallup-Healthways) of a representative community sample of 18,614 U.S. respondents, including 4,425 younger (age 18 to 39 years), 6,365 middle-aged (40 to 59 years), and 7,824 older (60 to 99 years) adults. The surveyors collected data on demographics, lifestyles, and medical information. Less education, smoking, hypertension, diabetes, less exercise, obesity and depression, and interactions among them, were examined for associations with SMI. Weighted logistic regressions and chi-square tests were used to calculate odds ratios and confidence intervals for SMI with each risk factor and pairwise interactions across age groups. Depression, less education, less exercise, and hypertension were significantly associated with SMI in all three age groups. Several interactions between risk factors were significant in younger and middle-aged adults and influenced their associations with SMI. Frequency of SMI increased with age and number of risk factors. Odds of having SMI increased significantly with just having one risk factor. These results indicate that modifiable risk factors for AD are also associated with SMI, suggesting that these relationships occur in a broad range of ages and may be targeted to mitigate further memory problems. Whether modifying these risk factors reduces SMI and the eventual incidence of AD and other dementias later in life remains to be determined.
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通讯作者：
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