Chemical Tuning of Fibers Drawn from Extensible Hyaluronic Acid Networks.
Chemical Tuning of Fibers Drawn from Extensible Hyaluronic Acid Networks.
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DOI：
10.1021/jacs.0c09691
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发表时间：
2020-11-18
影响因子：
15
通讯作者：
Anderson, Daniel G.
中科院分区：
文献类型：
--
作者：
Chu, Crystal K.;Joseph, Alby J.;Limjoco, Matthew D.;Yang, Jiawei;Bose, Suman;Thapa, Lavanya S.;Langer, Robert;Anderson, Daniel G.
具有特定化学和机械性能的聚合物纤维是用于再生医学和药物递送的许多生物材料的关键组分。在这里，我们开发了一种生物启发的低能耗工艺，以生产从水溶液中提取的机械可调生物聚合物纤维。透明质酸（HA）与用不同结构的硼酸末端官能化的支化聚乙二醇聚合物形成动态交联以产生可延伸的聚合物网络。这种动态纤维前体（DFP）通过制浆直接拉伸成HA纤维，其显示高纵横比，直径范围为4-20微米，长度高达约10米。DFP的动态流变学测量和所得纤维的拉伸测试揭示了调整纤维形成倾向和纤维机械性能的设计考虑，包括聚合物结构和浓度对弹性模量、拉伸强度和极限应变的影响。这种材料的湿度响应性收缩行为是蜘蛛丝在合成材料中很少观察到的独特性质，这突出了进一步仿生和刺激响应纤维应用的可能性。这项工作表明，动态相互作用的化学改性可用于调整拉挤基纤维及其前体的机械性能。
Polymer fibers with specific chemical and mechanical properties are key components of many biomaterials used for regenerative medicine and drug delivery. Here we develop a bioinspired, low-energy process to produce mechanically tunable biopolymer fibers drawn from aqueous solutions. Hyaluronic acid (HA) forms dynamic crosslinks with branched polyethylene glycol polymers end-functionalized with boronic acids of varied structure to produce extensible polymer networks. This dynamic fiber precursor (DFP) is directly drawn by pultrusion into HA fibers that display high aspect ratios, ranging from 4–20 microns in diameter and up to ~10 meters in length. Dynamic rheology measurements of the DFP and tensile testing of the resulting fibers reveal design considerations to tune the propensity for fiber formation and fiber mechanical properties, including the effect of polymer structure and concentration on elastic modulus, tensile strength, and ultimate strain. The materials’ humidity-responsive contractile behavior, a unique property of spider silks rarely observed in synthetic materials, highlights possibilities for further biomimetic and stimulus-responsive fiber applications. This work demonstrates that chemical modification of dynamic interactions can be used to tune the mechanical properties of pultrusion-based fibers and their precursors.
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影响因子：
3.1
作者：
Weng L;Xie J
通讯作者：
Xie J
影响因子：
41.2
作者：
Chaudhuri O;Gu L;Klumpers D;Darnell M;Bencherif SA;Weaver JC;Huebsch N;Lee HP;Lippens E;Duda GN;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
29.4
作者：
Davidson, Matthew D.;Ban, Ehsan;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
5.1
作者：
Smitthipong, Wirasak;Suethao, Sukontip;Vollrath, Fritz
通讯作者：
Vollrath, Fritz
影响因子：
14
作者：
Ji, Y;Ghosh, K;Rafailovich, MH
通讯作者：
Rafailovich, MH