Patterning and compartment formation in the diencephalon.

Patterning and compartment formation in the diencephalon.
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DOI:
10.3389/fnins.2012.00066
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发表时间:
2012
影响因子:
4.3
通讯作者:
Li JY
Li JY
中科院分区:
医学2区
文献类型:
--
作者:
Chatterjee M;Li JY

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间脑产生的结构在连接前脑与中枢神经系统的其余部分方面起着重要作用。丘脑是间脑的主要衍生物,其功能是皮层和其他低级感觉系统之间的中继站。近二十年前,神经/proomeric模型被提出来描述间脑的细分和潜在的分割。与皮层的层状结构不同,间脑逐渐分为不同的功能区室,主要由丘脑、上丘脑、顶盖前区和下丘脑组成。这些区域内产生的神经元进一步聚集形成称为细胞核的簇,形成特定的结构和功能单位。我们回顾了最近的进展,了解遗传机制,参与图案和隔室形成的间脑。
The diencephalon gives rise to structures that play an important role in connecting the anterior forebrain with the rest of the central nervous system. The thalamus is the major diencephalic derivative that functions as a relay station between the cortex and other lower order sensory systems. Almost two decades ago, neuromeric/prosomeric models were proposed describing the subdivision and potential segmentation of the diencephalon. Unlike the laminar structure of the cortex, the diencephalon is progressively divided into distinct functional compartments consisting principally of thalamus, epithalamus, pretectum, and hypothalamus. Neurons generated within these domains further aggregate to form clusters called nuclei, which form specific structural and functional units. We review the recent advances in understanding the genetic mechanisms that are involved in the patterning and compartment formation of the diencephalon.
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