The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
复制标题
脊髓损伤后经脊髓磁刺激的再生效应： 脊髓损伤后的再生效应：效应的机制和途径。
DOI：
10.1007/s13311-020-00915-5
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Guérout N
中科院分区：
文献类型：
--
作者：
Chalfouh C;Guillou C;Hardouin J;Delarue Q;Li X;Duclos C;Schapman D;Marie JP;Cosette P;Guérout N
脊髓损伤（SCI）导致敏感和运动功能的丧失。目前，没有治疗干预提供完全恢复。在这里，我们报告说，重复的经脊髓磁刺激（rTSMS）可以是一种非侵入性的SCI治疗，增强组织修复和功能恢复。已经进行了几种技术，包括免疫组织化学，行为，细胞培养和蛋白质组学。此外，不同的病变范例，如急性和慢性期后SCI野生型和转基因动物在不同年龄（少年，成年人，老年人），已被使用。我们证明rTSMS通过减少纤维化和炎症以及增加脊髓干细胞的增殖来调节损伤瘢痕。我们的研究结果还表明，rTSMS减少脱髓鞘，这有助于轴突再生，神经元存活，和运动恢复后SCI。这项研究提供了证据表明，rTSMS在临床前啮齿动物模型中诱导治疗效果，并表明可能转化为人类的临床应用。本文的在线版本（10.1007/s13311-020-00915-5）包含补充材料，可供授权用户使用。
Spinal cord injury (SCI) leads to a loss of sensitive and motor functions. Currently, there is no therapeutic intervention offering a complete recovery. Here, we report that repetitive trans-spinal magnetic stimulation (rTSMS) can be a noninvasive SCI treatment that enhances tissue repair and functional recovery. Several techniques including immunohistochemical, behavioral, cells cultures, and proteomics have been performed. Moreover, different lesion paradigms, such as acute and chronic phase following SCI in wild-type and transgenic animals at different ages (juvenile, adult, and aged), have been used. We demonstrate that rTSMS modulates the lesion scar by decreasing fibrosis and inflammation and increases proliferation of spinal cord stem cells. Our results demonstrate also that rTSMS decreases demyelination, which contributes to axonal regrowth, neuronal survival, and locomotor recovery after SCI. This research provides evidence that rTSMS induces therapeutic effects in a preclinical rodent model and suggests possible translation to clinical application in humans. The online version of this article (10.1007/s13311-020-00915-5) contains supplementary material, which is available to authorized users.
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影响因子：
64.5
作者：
Dias DO;Kim H;Holl D;Werne Solnestam B;Lundeberg J;Carlén M;Göritz C;Frisén J
通讯作者：
Frisén J
影响因子：
13.6
作者：
Dufor, T.;Grehl, S.;Sherrard, R. M.
通讯作者：
Sherrard, R. M.
影响因子：
3.5
作者：
Cullen CL;Young KM
通讯作者：
Young KM
影响因子：
14.5
作者：
Chort, Alice;Alves, Sandro;Sittler, Annie
通讯作者：
Sittler, Annie
DOI：
10.1007/s00259-009-1342-3
发表时间：
2010-05-01
影响因子：
9.1
作者：
Gao, Feng;Wang, Shuang;Zhang, Hong
通讯作者：
Zhang, Hong