Blood culture in the first 6 months of life for the diagnosis of vertically transmitted human immunodeficiency virus infection. The Women and Infants Transmission Study Group.

Blood culture in the first 6 months of life for the diagnosis of vertically transmitted human immunodeficiency virus infection. The Women and Infants Transmission Study Group.
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生命前 6 个月的血培养用于诊断垂直传播的人类免疫缺陷病毒感染。

DOI:
10.1093/infdis/170.4.996
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发表时间:
1994
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Rich,K
Rich,K
中科院分区:
--
文献类型:
--
作者:
McIntosh,K;Pitt,J;Brambilla,D;Carroll,S;Diaz,C;Handelsman,E;Moye,J;Rich,K

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在妇女和婴儿传播研究中,对310名垂直暴露于人类免疫缺陷病毒(HIV)的婴儿在出生后前6个月的连续血培养进行了分析,以确定其对HIV感染早期诊断的价值。在0-7天和1、2、4和6个月大时进行培养:55名婴儿被感染。感染儿童的血培养敏感性在出生后第一周为24%(7/29),在1、2、4和6个月时分别为85%、91%、82%和88%。1 ~ 6月龄的单个培养物的敏感性、特异性、阳性和阴性预测值分别为86.9%、99.6%、97.9%和97.5%。1 ~ 6月龄的两个阴性培养物定义为未感染婴儿,特异性为99.2%~ 100.0%。在HIV阳性母亲的孩子1至6个月大时进行的血培养是HIV感染的敏感和特异性测试,具有较高的阳性和阴性预测值。
Serial blood cultures over the first 6 months of life in 310 infants with vertical exposure to human immunodeficiency virus (HIV) in the Women and Infants Transmission Study were analyzed to determine their value for early diagnosis of HIV infection. Cultures were done at 0–7 days and 1, 2, 4, and 6 months of age: 55 infants were infected. Blood culture sensitivity in infected children was 24% (7/29) during the first week of life and 85%, 91%, 82%, and 88%, respectively, at 1, 2, 4, and 6 months. The sensitivity, specificity, and positive and negative predictive values of a single culture between 1 and 6 months of age were, respectively, 86.9%, 99.6%, 97.9%, and 97.5%. Two negative cultures between 1 and 6 months of age defined an uninfected infant with a specificity of 99.2%-100.0%. Blood culture done between 1 and 6 months of age in children of HIV-positive mothers is a sensitive and specific test for HIV infection, with high positive and negative predictive values.
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