The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.

The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.
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DOI:
10.1002/dvdy.471
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发表时间:
2022-08
期刊:
Developmental dynamics : an official publication of the American Association of Anatomists
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古典解剖学家德鲁·诺登(Drew Noden)率先开展了颅面研究,为我们对颅面骨骼发育、进化和疾病的现代分子理解奠定了基础。他的工作揭示了头部肌肉组织的起源和颅神经嵴在头部肌肉骨骼结构的早期形成和模式中的作用。现代颅腱研究的大部分进展都是Noden利用经典的鹌鹑-小鸡移植实验建立的知识基础。这种优雅的禽类嵌合系统包括将供体鹌鹑细胞移植到宿主鸡胚中,以确定它们可以形成的细胞类型及其与周围组织的相互作用。在这篇综述中,我们将简要介绍脊椎动物头部形成的背景以及颅神经嵴对头部肌肉骨骼附着的模式、发育和进化的影响。使用斑马鱼作为模型系统,我们将讨论颅面结构在进化中的修改的例子,特别关注肌腱和韧带的作用。最后,我们将讨论颅面肌腱的病理学,以及了解人类疾病颅面肌腱发育过程中分子和细胞动力学的重要性。
The classical anatomist Drew Noden spearheaded craniofacial research, laying the foundation for our modern molecular understanding of development, evolution and disorders of the craniofacial skeleton. His work revealed the origin of cephalic musculature and the role of cranial neural crest in early formation and patterning of the head musculoskeletal structures. Much of modern cranial tendon research advances a foundation of knowledge that Noden built using classical quail-chick transplantation experiments. This elegant avian chimeric system involves grafting of donor quail cells into host chick embryos to identify the cell types they can form and their interactions with the surrounding tissues. In this review, we will give a brief background of vertebrate head formation and the impact of cranial neural crest on the patterning, development and evolution of the head musculoskeletal attachments. Using the zebrafish as a model system, we will discuss examples of modifications of craniofacial structures in evolution with a special focus on the role of tendon and ligaments. Lastly, we will discuss pathologies in craniofacial tendons and the importance of understanding the molecular and cellular dynamics during craniofacial tendon development in human disease.
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