The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells.

The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells.
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树突状细胞在滤泡辅助 T 细胞分化中的作用

DOI:
10.1155/2018/7281453
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发表时间:
2018
影响因子:
4.1
通讯作者:
Yang W
Yang W
中科院分区:
医学3区
文献类型:
--
作者:
Zou X;Sun G;Huo F;Chang L;Yang W

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T滤泡辅助细胞(TFH)是最近发现的CD4+T细胞的一个子集。其主要功能是参与生殖中心(GCs)的形成,促进B细胞增殖和分化,在抗体产生中发挥重要作用。目前,TFH细胞的功能已经明确。然而,这些细胞的早期分化尚不清楚。树突状细胞(Dendritic cells,DC)参与TFH细胞的分化。本文就DC对TFH细胞分化的影响及其主要机制的研究进展作一综述。
T follicular helper cells (TFH) are a subset of recently discovered CD4+T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of TFHcells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of TFHcells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of TFHcells and their major underlying mechanisms.
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