Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects.
Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects.
复制标题
健康中国受试者矢量诱发恶心期间的下丘脑和胃肌电反应。
DOI：
10.1152/ajpendo.1993.265.4.e578
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Bingaman,S
中科院分区：
文献类型：
--
作者：
Xu,LH;Koch,KL;Summy-Long,J;Stern,RM;Seaton,JF;Harrison,TS;Demers,LM;Bingaman,S
恶心是人类特有的一种症状，其生理学机制尚不清楚。本研究的目的是测量的时间序列的神经激素反应和胃肌电活动的健康受试者在旋转的视动鼓，产生恶心和其他症状的晕动病。在基线时、滚筒旋转1-5分钟、6-10分钟和11- 1 - 5分钟期间以及旋转停止后测量血浆儿茶酚胺、加压素和皮质醇。在整个研究期间记录胃电图。12例受试者（80%）发生恶心和4-9个周期/分钟的胃快速性心律失常; 3例受试者无恶心和胃节律障碍。快速性心律失常在转鼓开始后3.4 ± 0.8分钟开始，平均3分钟后报告恶心。在转鼓6-10分钟内，有恶心症状者的垂体后叶素水平显著高于无恶心症状者（P < 0.04）。在有恶心症状的受试者中，在转鼓6-10分钟和11-15分钟，肾上腺素和加压素较基线显著增加（P < 0.05）。随着恶心在恢复期间消退，血管加压素减少74%，而肾上腺素增加13%。我们的结论是：1）在麻醉受试者中，内源性加压素和交感神经回路在下丘脑-垂体-肾上腺途径之前被激活，2）血浆加压素水平与恶心的时间发作和消退最密切相关，3）外周胃节律障碍可能在激活中枢加压素能神经元中起作用。
The physiology of nausea, a uniquely human symptom, is poorly understood. The purpose of this study was to measure the temporal sequences of neurohormonal responses and gastric myoelectrical activity in healthy subjects during the rotation of an optokinetic drum that produced nausea and other symptoms of motion sickness. Plasma catecholamines, vasopressin, and cortisol were measured at baseline, during minutes 1-5, 6-10, and 11-15 of drum rotation, and after rotation stopped. Electrogastrograms were recorded throughout the study. Twelve subjects (80%) developed nausea and 4-9 cycles/min of gastric tachyarrhythmias; three subjects had no nausea and no gastric dysrhythmias. Tachyarrhythmias began 3.4 +/- 0.8 min after the onset of drum rotation, and nausea was reported, on average, 3 min later. During minutes 6-10 of drum rotation, vasopressin levels significantly increased in the subjects with nausea compared with subjects without nausea (P < 0.04). In the subjects with nausea, epinephrine and vasopressin increased significantly (P < 0.05) compared with baseline during minutes 6-10 and 11-15 of drum rotation. As nausea resolved during recovery, vasopressin decreased by 74%, whereas epinephrine increased 13%. We conclude that 1) in nauseated subjects, endogenous vasopressinergic and sympathetic circuits are activated before hypothalamic-pituitary-adrenal pathways, 2) plasma vasopressin levels correlate most closely with the temporal onset and resolution of nausea, and 3) peripheral gastric dysrhythmias may have a role in activating central vasopressinergic neurons.
登录
查看更多内容
胃心动过速和晕动病。
影响因子：
--
作者：
R. Stern;Kenneth L. Koch;Herschel W. Leibowitz;Lindblad Im;Shupert Cl;William R. Stewart
通讯作者：
William R. Stewart
DOI：
--
发表时间：
1993
期刊：
影响因子：
--
作者：
K. Koch;T. Tran;R. Stern;S. Bingaman;N. Sperry
通讯作者：
N. Sperry
加压素和催产素对人类幻觉自我运动和恶心的反应。
影响因子：
5.8
作者：
K. Koch;J. Summy;S. Bingaman;N. Sperry;R. Stern
通讯作者：
R. Stern
阿扑吗啡引起的人类恶心：加压素和胰多肽的释放。
影响因子：
29.4
作者：
Feldman,M;Samson,WK;O'Dorisio,TM
通讯作者：
O'Dorisio,TM
急性应激后脱水大鼠血浆加压素水平降低。
影响因子：
4.8
作者：
L. Keil;W. Severs
通讯作者：
W. Severs