Prospective study of dietary patterns and colorectal cancer among Singapore Chinese.

Prospective study of dietary patterns and colorectal cancer among Singapore Chinese.
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DOI:
10.1038/sj.bjc.6604678
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发表时间:
2008-11-04
影响因子:
8.8
通讯作者:
Yu, M. C.
Yu, M. C.
中科院分区:
医学1区
文献类型:
--
作者:
Butler, L. M.;Wang, R.;Koh, W-P;Yu, M. C.

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在新加坡华人中观察到的西方饮食和生活方式因素的影响可能导致了该人群在过去二十年中结直肠癌发病率的显着上升。然而,到目前为止,几乎没有证据表明个别营养素和食物是该人群的主要影响因素。我们在1993年至1998年建立的61,321名新加坡中国人的人群队列中评估了食物摄入模式是否与结直肠癌相关。两种饮食模式,肉类点心和蔬菜,水果,大豆,先前确定的主成分分析使用基线饮食数据,从一个有效的165项食物频率问卷。截至2005年12月31日,诊断出961例结肠直肠癌病例。比例风险回归用于计算调整后的风险比。使用近10年的随访数据,我们观察到与结直肠癌的肉类-点心或蔬菜-水果-大豆模式无关。总之,无论是个别营养素或食物,也没有饮食模式似乎可以解释大肠癌的新加坡华人人口的上升。
An influence of Western diet and lifestyle factors observed among Singapore Chinese may contribute to the population's marked rise in colorectal cancer incidence over the past two decades. Thus far, however, there is little evidence for individual nutrients and foods as major contributing factors in this population. We evaluated whether patterns of food intake were associated with colorectal cancer in a population-based cohort of 61,321 Singapore Chinese that was established in 1993–98. Two dietary patterns, meat–dim sum and vegetable–fruit–soy, were previously identified by principal components analysis using baseline dietary data from a validated 165-item food frequency questionnaire. As of 31 December 2005, 961 incident colorectal cancer cases were diagnosed. Proportional hazards regression was used to calculate adjusted hazard ratios. Using nearly 10 years of follow-up data, we observed no association with either the meat–dim sum or vegetable–fruit–soy pattern for colorectal cancer. In conclusion, neither individual nutrients or foods nor dietary patterns appear to explain the rise in colorectal cancer among Singapore Chinese population.
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