Hippocampal and ventral medial prefrontal activation during retrieval-mediated learning supports novel inference.
Hippocampal and ventral medial prefrontal activation during retrieval-mediated learning supports novel inference.
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DOI：
10.1016/j.neuron.2012.05.010
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发表时间：
2012-07-12
期刊：
影响因子：
16.2
通讯作者：
Preston AR
中科院分区：
文献类型：
--
作者：
Zeithamova D;Dominick AL;Preston AR
记忆使人们能够灵活地使用过去的经验来指导新的行为。虽然主流理论假设这种基本的灵活性来自于与多种经历相关的整合记忆网络的形成，但支持记忆整合的神经机制还没有得到很好的理解。在这里，我们证明了检索介导的学习，即先前的事件细节在相关经验的编码过程中恢复，支持参与者推断共享内容的不同事件之间的关系的能力。此外，我们表明，激活功能耦合海马和腹内侧前额叶皮层回路的变化跟踪形成的综合记忆和成功的推理记忆性能。这些研究结果的特点，这些区域在检索介导的学习过程中，支持关系记忆网络的形成和推理记忆在人脑中的各自的作用。更广泛地说，这些数据揭示了记忆表征被构建成前瞻性有用格式的基本机制。
Memory enables flexible use of past experience to inform new behaviors. Though leading theories hypothesize that this fundamental flexibility results from the formation of integrated memory networks relating multiple experiences, the neural mechanisms that support memory integration are not well understood. Here, we demonstrate that retrieval-mediated learning, whereby prior event details are reinstated during encoding of related experiences, supports participants’ ability to infer relationships between distinct events that share content. Furthermore, we show that activation changes in a functionally coupled hippocampal and ventral medial prefrontal cortical circuit track the formation of integrated memories and successful inferential memory performance. These findings characterize the respective roles of these regions in retrieval-mediated learning processes that support relational memory network formation and inferential memory in the human brain. More broadly, these data reveal fundamental mechanisms through which memory representations are constructed into prospectively useful formats.
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影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
DOI：
10.1073/pnas.94.13.7109
发表时间：
1997-06-24
影响因子：
11.1
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
3.5
作者：
DeVito, Loren M.;Kanter, Benjamin R.;Eichenbaum, Howard
通讯作者：
Eichenbaum, Howard
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
25
作者：
Karlsson, Mattias P.;Frank, Loren M.
通讯作者：
Frank, Loren M.