The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases.
The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases.
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DOI：
10.3389/fimmu.2020.609752
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发表时间：
2020
影响因子：
7.3
通讯作者：
Aoki H
中科院分区：
文献类型：
--
作者：
Matsumoto KI;Aoki H
腱生蛋白是一类多功能细胞外基质糖蛋白家族，在发育、组织稳态和疾病过程中具有时间和组织特异性表达模式。在脊椎动物中有四个家族成员（腱生蛋白-C、-R、-X、-W）。其中，腱生蛋白-X（tenascin-X，TNX）和腱生蛋白-C（tenascin-C，TNC）在人类病理学中起重要作用。TNX在疏松结缔组织中广泛表达。TNX有助于胶原蛋白网络的稳定和维持，其缺乏会导致经典样埃勒斯-当洛斯综合征（clEDS），一种遗传性结缔组织疾病。相反，TNC在病理条件如炎症、纤维化和癌症时特异性和瞬时表达。越来越多的证据表明，TNC以依赖于环境的方式参与具有促炎或抗炎活性的炎症过程。在这篇综述中，我们总结了这两个腱生蛋白，TNX和TNC，在心血管和炎症性疾病和clEDS中的作用，我们讨论了这些腱生蛋白的表达组织稳态的功能后果。
Tenascins are a family of multifunctional extracellular matrix (ECM) glycoproteins with time- and tissue specific expression patterns during development, tissue homeostasis, and diseases. There are four family members (tenascin-C, -R, -X, -W) in vertebrates. Among them, tenascin-X (TNX) and tenascin-C (TNC) play important roles in human pathologies. TNX is expressed widely in loose connective tissues. TNX contributes to the stability and maintenance of the collagen network, and its absence causes classical-like Ehlers-Danlos syndrome (clEDS), a heritable connective tissue disorder. In contrast, TNC is specifically and transiently expressed upon pathological conditions such as inflammation, fibrosis, and cancer. There is growing evidence that TNC is involved in inflammatory processes with proinflammatory or anti-inflammatory activity in a context-dependent manner. In this review, we summarize the roles of these two tenascins, TNX and TNC, in cardiovascular and inflammatory diseases and in clEDS, and we discuss the functional consequences of the expression of these tenascins for tissue homeostasis.
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
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DOI：
10.1083/jcb.201308031
发表时间：
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期刊：
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作者：
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