Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: a randomized controlled trial.
Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: a randomized controlled trial.
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DOI：
10.3945/ajcn.116.140780
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Gray SR
中科院分区：
文献类型：
--
作者：
Da Boit M;Sibson R;Sivasubramaniam S;Meakin JR;Greig CA;Aspden RM;Thies F;Jeromson S;Hamilton DL;Speakman JR;Hambly C;Mangoni AA;Preston T;Gray SR
背景：抗阻运动可以增加老年人的肌肉质量和功能，但与年轻人相比，反应会减弱。数据表明，长链 n-3 多不饱和脂肪酸 (PUFA) 可能会增强老年女性对抗阻运动的适应能力。据我们所知，这种可能性尚未在男性中进行过研究。目的：我们试图确定补充长链 n-3 PUFA 对阻力运动训练引起的肌肉质量和功能增加的影响，以及这些影响在老年男性和女性之间是否存在差异。设计：50 名男性和女性 [男性：n = 27，平均值 ± SD 年龄：70.6 ± 4.5 岁，平均值 ± SD 体重指数（BMI；单位为 kg/m2）：25.6 ± 4.2；女性：n = 23，平均值±SD年龄：70.7±3.3岁，平均值±SD BMI：25.3±4.7]被随机分配至长链n-3 PUFA（n = 23；3 g鱼油/天）或安慰剂（n = 27；3 g红花油/天），并参加每周两次的下肢阻力运动训练，持续18周。在干预前后测量肌肉大小、力量和质量（单位肌肉面积的力量）、功能能力以及循环代谢和炎症标志物。结果：运动训练后，女性长链 n-3 PUFA 组的最大等长扭矩增加程度高于安慰剂组 (P < 0.05)，而男性各组之间没有差异 (P > 0.05)。在男女中，运动训练对 30、90 和 240° s−1 时的最大等速扭矩、4 米步行时间、椅子起立时间、肌肉解剖横截面积和肌肉脂肪的影响在组间没有差异 (P > 0.05)。长链 n-3 PUFA 组运动训练后，女性的肌肉质量比安慰剂组有更大的提高 (P < 0.05)，而男性则没有这种差异 (P > 0.05)。与安慰剂相比，长链 n-3 PUFA 导致男女血浆甘油三酯浓度显着降低 (P < 0.05)，而葡萄糖、胰岛素或炎症标志物没有差异 (P > 0.05)。结论：长链 n-3 PUFA 补充剂可增强老年女性的肌肉功能和质量，但不会增强老年男性在抗阻运动训练后的肌肉功能和质量。该试验在 ClinicalTrials.gov 上注册为 NCT02843009。
Background: Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n–3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance exercise in older women. To our knowledge, this possibility has not been investigated in men. Objective: We sought to determine the effects of long-chain n–3 PUFA supplementation on resistance exercise training–induced increases in muscle mass and function and whether these effects differ between older men and women. Design: Fifty men and women [men: n = 27, mean ± SD age: 70.6 ± 4.5 y, mean ± SD body mass index (BMI; in kg/m2): 25.6 ± 4.2; women: n = 23, mean ± SD age: 70.7 ± 3.3 y, mean ± SD BMI: 25.3 ± 4.7] were randomly assigned to either long-chain n–3 PUFA (n = 23; 3 g fish oil/d) or placebo (n = 27; 3 g safflower oil/d) and participated in lower-limb resistance exercise training twice weekly for 18 wk. Muscle size, strength, and quality (strength per unit muscle area), functional abilities, and circulating metabolic and inflammatory markers were measured before and after the intervention. Results: Maximal isometric torque increased after exercise training to a greater (P < 0.05) extent in the long-chain n–3 PUFA group than in the placebo group in women, with no differences (P > 0.05) between groups in men. In both sexes, the effect of exercise training on maximal isokinetic torque at 30, 90, and 240° s−1, 4-m walk time, chair-rise time, muscle anatomic cross-sectional area, and muscle fat did not differ (P > 0.05) between groups. There was a greater (P < 0.05) increase in muscle quality in women after exercise training in the long-chain n–3 PUFA group than in the placebo group, with no such differences in men (P > 0.05). Long-chain n–3 PUFAs resulted in a greater decrease (P < 0.05) than the placebo in plasma triglyceride concentrations in both sexes, with no differences (P > 0.05) in glucose, insulin, or inflammatory markers. Conclusion: Long-chain n–3 PUFA supplementation augments increases in muscle function and quality in older women but not in older men after resistance exercise training. This trial was registered at clinicaltrials.gov as NCT02843009.
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DOI：
10.1016/j.clnu.2011.08.013
发表时间：
2011-12
期刊：
Clinical nutrition (Edinburgh, Scotland)
影响因子：
--
作者：
Akinkuolie AO;Ngwa JS;Meigs JB;Djoussé L
通讯作者：
Djoussé L
影响因子：
4.5
作者：
Burd, Nicholas A;West, Daniel Wd;Phillips, Stuart M
通讯作者：
Phillips, Stuart M
影响因子：
6.5
作者：
Bergeron, Karen;Julien, Pierre;Thivierge, M. Carole
通讯作者：
Thivierge, M. Carole
影响因子：
5.5
作者：
Damas, Felipe;Phillips, Stuart M.;Ugrinowitsch, Carlos
通讯作者：
Ugrinowitsch, Carlos
DOI：
10.1016/b978-0-12-397803-5.00020-4
发表时间：
2014-01-01
期刊：
INFLAMMATION, ADVANCING AGE AND NUTRITION: RESEARCH AND CLINICAL INTERVENTIONS, 1ST EDITION
影响因子：
--
作者：
Degens, Hans;McPhee, Jamie S.
通讯作者：
McPhee, Jamie S.