Omega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trials.
Omega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trials.
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DOI：
10.1016/j.clnu.2011.08.013
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Djoussé L
中科院分区：
文献类型：
--
作者：
Akinkuolie AO;Ngwa JS;Meigs JB;Djoussé L
N-3多不饱和脂肪酸已被证明可以降低代谢综合征的几个组成部分的风险；然而，n-3多不饱和脂肪酸对糖代谢的作用尚不清楚。我们的目的是通过对可用的随机对照试验进行荟萃分析，系统地审查n-3多不饱和脂肪酸对体制建设的影响。我们遵循Cochrane对系统干预的审查指南。我们搜索了MEDLINE、EMBASE、Central和Clinicaltrials.gov，从每个数据库的开头到2010年10月。使用随机效应模型进行Meta分析以估计合并的SMD和相应的95%可信区间。在303篇筛选的引文中，有11篇随机对照试验(n=618)符合纳入分析的条件。在合并估计中，与安慰剂相比，n-3多不饱和脂肪酸干预对IS没有影响(SMD0.08，95%CI−0.11−0.28)。同样，在分组分析中，n-3多不饱和脂肪酸对IS没有影响(2型糖尿病与其他人群；Quicki和其他测试亚组)。在HOMA亚组中，与安慰剂相比，n-3多不饱和脂肪酸与IS显著相关(SMD为0.30，CI为0.03-0.58)。这一元分析与缺乏n-3多不饱和脂肪酸对IS的影响是一致的。
n-3 PUFA has been shown to decrease the risk of several components of the metabolic syndrome; however, the role of n-3 PUFA on glucose metabolism is not clear. Our aim was to systematically review the effect of n-3 PUFA on IS by conducting a meta-analysis of available RCTs. We followed the guidelines of Cochrane’s review of systematic interventions. We searched MEDLINE, EMBASE, CENTRAL and clinicaltrials.gov from the beginning of each database until October 2010. Meta-analysis was performed using a random effects model to estimate a pooled SMD and the corresponding 95% CI. From 303 screened citations, 11 RCTs (n = 618) were eligible for inclusion in the analysis. In a pooled estimate, n-3 PUFA intervention had no effects on IS compared to placebo (SMD 0.08, 95% CI −0.11 −0.28). Similarly, n-3 PUFA had no effects on IS in sub-group analyses (Type 2 diabetes vs. other population; QUICKI and other test subgroups). In the HOMA subgroup, n-3 PUFA was associated with a statistically significant increase in IS (SMD 0.30, CI 0.03–0.58) when compared to placebo. This meta-analysis is consistent with a lack of n-3 PUFA effects on IS.
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影响因子：
7.1
作者：
Djousse, Luc;Gaziano, J. Michael;Lee, I-Min
通讯作者：
Lee, I-Min
影响因子：
39.2
作者：
GLAUBER, H;WALLACE, P;BRECHTEL, G
通讯作者：
BRECHTEL, G
影响因子：
5.3
作者：
ANNUZZI, G;RIVELLESE, A;RICCARDI, G
通讯作者：
RICCARDI, G
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
7.1
作者：
Harris, WS
通讯作者：
Harris, WS