Individual differences in EEG correlates of recognition memory due to DAT polymorphisms.
Individual differences in EEG correlates of recognition memory due to DAT polymorphisms.
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DOI：
10.1002/brb3.870
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发表时间：
2017-12
影响因子：
3.1
通讯作者：
Ross RS
中科院分区：
文献类型：
--
作者：
Medrano P;Nyhus E;Smolen A;Curran T;Ross RS
虽然先前的研究表明，多巴胺能基因的遗传变异可能会影响再认记忆，但多巴胺转运体的表达对再认记忆的行为和脑电相关性的作用尚未得到很好的证实。这项研究旨在揭示由于多巴胺转运体基因的遗传变异而导致的多巴胺能功能的个体差异如何影响行为和脑电与识别记忆的相关性。58名参与者完成了一项物品识别任务。参与者被要求提取200个先前呈现的单词，同时用脑电记录大脑活动。在与识别记忆相关的头皮位置建立感兴趣区域。将正确记忆旧物品(HITS)和识别新物品(正确拒绝)时的平均ERP波幅和事件相关频谱扰动作为多巴胺转运体组的函数进行比较。与多巴胺转运体(9R携带者)表达较少相关的多巴胺转运体组的参与者相比，编码增加的多巴胺转运体表达的多巴胺转运体组(10/10纯合子)的参与者表现出较慢的反应时间。与9R携带者相比，10/10纯合子的事件相关电位和振荡活动也有差异。10/10纯合子不能显示左顶叶旧/新效应，即与提取的信息量相关的识别记忆的事件相关电位信号。与9R携带者相比，10/10纯合子在项目记忆提取过程中，α和β振荡活动的下降幅度也更大。与9R携带者相比，10/10纯合子在再认记忆过程中表现出较慢的击中和正确的排斥反应时间，没有左顶叶旧/新效应，并且α和β振荡活动的下降幅度更大。这些结果表明，多巴胺转运体基因多态性影响再认记忆。
Although previous research suggests that genetic variation in dopaminergic genes may affect recognition memory, the role dopamine transporter expression may have on the behavioral and EEG correlates of recognition memory has not been well established. The study aims to reveal how individual differences in dopaminergic functioning due to genetic variations in the dopamine transporter gene influences behavioral and EEG correlates of recognition memory. Fifty‐eight participants performed an item recognition task. Participants were asked to retrieve 200 previously presented words while brain activity was recorded with EEG. Regions of interest were established in scalp locations associated with recognition memory. Mean ERP amplitudes and event‐related spectral perturbations when correctly remembering old items (hits) and recognizing new items (correct rejections) were compared as a function of dopamine transporter group. Participants in the dopamine transporter group that codes for increased dopamine transporter expression (10/10 homozygotes) display slower reaction times compared to participants in the dopamine transporter group associated with the expression of fewer dopamine transporters (9R‐carriers). 10/10 homozygotes further displayed differences in ERP and oscillatory activity compared to 9R‐carriers. 10/10 homozygotes fail to display the left parietal old/new effect, an ERP signature of recognition memory associated with the amount of information retrieved. 10/10 homozygotes also displayed greater decreases of alpha and beta oscillatory activity during item memory retrieval compared to 9R‐carriers. Compared to 9R‐carriers, 10/10 homozygotes display slower hit and correct rejection reaction times, an absence of the left parietal old/new effect, and greater decreases in alpha and beta oscillatory activity during recognition memory. These results suggest that dopamine transporter polymorphisms influence recognition memory.
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DOI：
10.1016/j.cub.2009.06.021
发表时间：
2009-08-11
期刊：
Current biology : CB
影响因子：
--
作者：
Bunzeck N;Doeller CF;Fuentemilla L;Dolan RJ;Duzel E
通讯作者：
Duzel E
影响因子：
7.6
作者：
Apitz, Thore;Bunzeck, Nico
通讯作者：
Bunzeck, Nico
影响因子：
5.3
作者：
Burke, John F.;Sharan, Ashwini D.;Kahana, Michael J.
通讯作者：
Kahana, Michael J.
DOI：
10.1073/pnas.1014528108
发表时间：
2011-06-28
影响因子：
11.1
作者：
Addante, Richard J.;Watrous, Andrew J.;Ranganath, Charan
通讯作者：
Ranganath, Charan
影响因子：
5.7
作者：
Eckart, Cindy;Fuentemilla, Lluis;Bunzeck, Nico
通讯作者：
Bunzeck, Nico