Tunable elastomer materials with vascular tissue-like rupture mechanics behavior
Tunable elastomer materials with vascular tissue-like rupture mechanics behavior
复制标题
具有类似血管组织破裂力学行为的可调谐弹性体材料
DOI：
10.1088/2057-1976/ac82f6
复制
发表时间：
2022
影响因子：
1.4
通讯作者：
Cardoso, Luis
中科院分区：
文献类型：
--
作者：
Corti, Andrea;Shameen, Tariq;Sharma, Shivang;De Paolis, Annalisa;Cardoso, Luis
目的建立人体动脉组织的实验室模型，有利于以一种简单、可控的方式研究血管的力学响应。在本研究中，我们调查了三个硅基材料复制的机械性能的人类动脉文献中记载的methodsWe进行单轴拉伸试验，以破裂Sylgard 184，Sylgard 170和DowsilEE-3200在不同的固化条件下，并获得其真实的（柯西）应力-应变行为和泊松比通过数字图像相关（DIC）。对于每一个配方，我们推导出的3项奥格登模型的本构参数和设计的数值模拟的管状模型下的径向压力为250 mmHg. ResultsEvery材料表现出明显的非线性超弹性和依赖于固化条件。Sylgard 184是最硬的配方，在相对低的应变下具有最高的剪切模量和极限应力（μ 184= 0.52-0.88 MPa，σ 184= 15.90-16.54 MPa，ε 184= 0.72-0.96）。相反，Sylgard 170和DowsilEE-3200呈现出显著更低的剪切模量和极限应力，更接近动脉组织报告的数据（μ 170= 0.33-0.7 MPa，σ 170= 2.61-3.67 MPa，ε 170= 0.69-0.81; μ dow= 0.02-0.09 MPa，σ dow= 0.83-2.05 MPa，ε dow= 0.91-1.05）。在径向压力作用下，除固化比为1：1的DowsilEE-3200外，其他所有配方的材料均承受0.1 ~ 0.18 MPa的弹性应力。结论Sylgard 170和DowsilEE-3200在其典型的极限应力和应变范围内能更好地再现血管组织的断裂行为。数值模型表明，所有三种材料均实现了与人类颈总动脉相似的周向应力（Sommer等人，2010），使得这些配方适用于生理和超生理负载下的圆柱形实验室模型。
PurposeLaboratory models of human arterial tissues are advantageous to examine the mechanical response of blood vessels in a simplified and controllable manner. In the present study, we investigated three silicone-based materials for replicating the mechanical properties of human arteries documented in the literature.MethodsWe performed uniaxial tensile tests up to rupture on Sylgard184, Sylgard170 and DowsilEE-3200 under different curing conditions and obtained their True (Cauchy) stress-strain behavior and Poisson's ratios by means of digital image correlation (DIC). For each formulation, we derived the constitutive parameters of the 3-term Ogden model and designed numerical simulations of tubular models under a radial pressure of 250 mmHg.ResultsEach material exhibits evident non-linear hyperelasticity and dependence on the curing condition. Sylgard184 is the stiffest formulation, with the highest shear moduli and ultimate stresses at relative low strains (μ 184= 0.52–0.88 MPa, σ 184= 15.90–16.54 MPa, ε 184= 0.72–0.96). Conversely, Sylgard170 and DowsilEE-3200 present significantly lower shear moduli and ultimate stresses that are closer to data reported for arterial tissues (μ 170= 0.33–0.7 MPa σ 170= 2.61–3.67 MPa, ε 170= 0.69–0.81; μ dow= 0.02–0.09 MPa σ dow= 0.83–2.05 MPa, ε dow= 0.91–1.05). Under radial pressure, all formulations except DowsilEE-3200 at 1: 1 curing ratio undergo circumferential stresses that remain in the elastic region with values ranging from 0.1 to 0.18 MPa.ConclusionSylgard170 and DowsilEE-3200 appear to better reproduce the rupture behavior of vascular tissues within their typical ultimate stress and strain range. Numerical models demonstrate that all three materials achieve circumferential stresses similar to human common carotid arteries (Sommer et al 2010), making these formulations suited for cylindrical laboratory models under physiological and supraphysiological loading.
影响因子：
2.4
作者：
Kural, Mehmet H.;Cai, Mingchao;Tang, Dalin;Gwyther, Tracy;Zheng, Jie;Billiar, Kristen L.
通讯作者：
Billiar, Kristen L.
影响因子：
2.4
作者：
Teng, Zhongzhao;Tang, Dalin;Zheng, Jie;Woodard, Pamela K.;Hoffman, Allen H.
通讯作者：
Hoffman, Allen H.
利用健康的猪主动脉创建患病动脉损伤和衰竭的模型。
DOI：
10.1016/j.jmbbm.2016.02.018
发表时间：
2016
影响因子：
3.9
作者：
Christopher Noble;Nicole Smulders;N. Green;R. Lewis;M. Carré;S. E. Franklin;S. MacNeil;Z. Taylor
通讯作者：
Z. Taylor