Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep.
Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep.
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DOI：
10.1167/iovs.18-25025
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发表时间：
2018-10-01
影响因子：
4.4
通讯作者：
Sigal IA
中科院分区：
文献类型：
--
作者：
Gogola A;Jan NJ;Lathrop KL;Sigal IA
为了检验人、猴、猪、绵羊、牛和山羊眼睛在后巩膜中表现出环形、放射状和交织胶原结构的假设。我们分析了来自4只人、4只猴、5只猪、8只绵羊、1只山羊和2只牛眼睛后极的1，327个冷冻切片。使用偏振光显微镜获取图像，并进行处理以获得极性纤维相对于根管中心的取向。周向，径向和交织区域进行了鉴定和分析的平均纤维取向和各向异性和区域宽度和厚度。每只眼睛表现出圆周，径向和交织纤维在一致的位置。在最内层的巩膜中，放射状纤维从管附近延伸到视乳头周围和周边巩膜。环形纤维直接邻近耳道，最常见于最外层的后巩膜。整个巩膜厚度中发现了交织的纤维。在所有物种中，径向，周向和交织区域的中位各向异性分别为0.95，0.96和0.28。人、猴、猪、绵羊、牛和山羊眼睛的后极巩膜中存在放射状、周向和交织纤维区域。巩膜结构的物种之间的一致性表明，他们是主要的组织组成部分，其功能应该得到更好的理解。
To test the hypothesis that human, monkey, pig, sheep, cow, and goat eyes exhibit circumferential, radial, and interweaving collagen architecture in the posterior sclera. We analyzed 1,327 cryosections from the posterior poles of 4 human, 4 monkey, 5 pig, 8 sheep, 1 goat, and 2 cow eyes. Images were acquired using polarized light microscopy and processed to obtain polar fiber orientations relative to the center of the canal. Circumferential, radial, and interweaving regions were identified and analyzed for mean fiber orientation and anisotropy and region width and thickness. Every eye exhibited circumferential, radial, and interweaving fibers in consistent locations. Radial fibers extended out from near the canal into the peripapillary and peripheral sclera in the innermost sclera. Circumferential fibers were directly adjacent to the canal and most prevalent in the outermost, posterior sclera. Interweaving fibers were found throughout the sclera thickness. Across all species, median anisotropy in the radial, circumferential, and interweaving regions were 0.95, 0.96, and 0.28, respectively. Regions of radial, circumferential, and interweaving fibers occur in the posterior pole sclera of human, monkey, pig, sheep, cow, and goat eyes. The consistency across species in scleral architecture suggests that they are primary organizational components whose functions should be better understood.
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影响因子：
4.4
作者：
Gogola A;Jan NJ;Brazile B;Lam P;Lathrop KL;Chan KC;Sigal IA
通讯作者：
Sigal IA
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4.2
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通讯作者：
NEUFELD, AH
影响因子：
4.4
作者：
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通讯作者：
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