Association of Cannabis Use During Adolescence With Neurodevelopment.
Association of Cannabis Use During Adolescence With Neurodevelopment.
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DOI：
10.1001/jamapsychiatry.2021.1258
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发表时间：
2021-06-16
期刊：
影响因子：
25.8
通讯作者：
IMAGEN Consortium
中科院分区：
文献类型：
--
作者：
Albaugh MD;Ottino-Gonzalez J;Sidwell A;Lepage C;Juliano A;Owens MM;Chaarani B;Spechler P;Fontaine N;Rioux P;Lewis L;Jeon S;Evans A;D'Souza D;Radhakrishnan R;Banaschewski T;Bokde ALW;Quinlan EB;Conrod P;Desrivières S;Flor H;Grigis A;Gowland P;Heinz A;Ittermann B;Martinot JL;Paillère Martinot ML;Nees F;Papadopoulos Orfanos D;Paus T;Poustka L;Millenet S;Fröhner JH;Smolka MN;Walter H;Whelan R;Schumann G;Potter A;Garavan H;IMAGEN Consortium
大麻的使用在多大程度上与青少年时期磁共振成像测量的大脑皮层厚度发展相关？在这项队列研究中，使用来自799名参与者的1598张磁共振图像进行的线性混合效应模型分析显示，大麻使用与14至19岁年龄相关的皮质变薄加速相关，主要是前额叶区域。大麻相关的皮质变薄的空间格局显着相关的正电子发射断层扫描评估地图大麻素1受体的可用性。结果表明，在青春期中后期使用大麻可能与大脑皮层发育的改变有关，特别是在富含大麻素1受体的区域。动物研究表明，青少年的大脑对内源性大麻素信号的中断很敏感，从而导致神经发育的改变和持久的行为影响。然而，很少有研究调查大麻使用与人类青少年大脑发育之间的关系。在青少年纵向样本中，研究磁共振（MR）成像评估的大脑皮质厚度发育与大麻使用相关的程度。数据来自在8个欧洲研究中心进行的基于社区的IMAGEN队列研究。本研究中使用的基线数据采集自2008年3月1日至2011年12月31日，随访数据采集自2013年1月1日至2016年12月31日。共有799名IMAGEN参与者被确定为在研究基线时报告大麻初治，并在基线和5年随访时提供了行为和神经影像学数据。统计分析时间为2019年10月1日至2020年8月31日。大麻的使用是在基线和5年的后续评估与欧洲学校调查项目酒精和其他药物。采用三维T1加权磁化梯度回波序列采集解剖MR图像。通过CIVET管道（版本2.1.0）处理质量受控的自体MR图像。该研究评价了799名受试者的1598张MR图像（450名女性受试者[56.3%];平均[SD]年龄，基线时14.4 [0.4]岁，随访时19.0 [0.7]岁）。在5年随访时，大麻使用（从0到>40次）与左前额叶厚度呈负相关（峰值：t785 =-4.87，簇大小= 1558个顶点; P = 1.10 × 10−6，随机场理论簇校正）和右前额叶（峰值：t785 =-4.27，集群大小= 1551个顶点; P = 2.81 × 10−5，随机场理论集群校正）皮层。5年随访时终生使用大麻与基线皮质厚度之间无显著相关性，表明观察到的神经解剖学差异并不先于开始使用大麻。纵向分析显示，年龄相关的皮质变薄是合格的大麻使用剂量依赖性的方式，使更多的使用，从基线到随访，与左前额叶皮层变薄增加（峰值：t815.27 =-4.24，群集大小= 3643个顶点; P = 2.28 × 10−8，随机场理论群集校正）和右前额叶（峰值：t813.30 =-4.71，簇大小= 2675个顶点; P = 3.72 × 10−8，随机场理论簇校正）皮层。在该样本中，大麻相关的变薄的空间模式与年龄相关的变薄相关（r = 0.540; P < .001），正电子发射断层扫描评估的大麻素1受体结合图来自一个单独的参与者样本（r =-0.189; P < .001）。分析显示，从基线到随访，右前额叶皮质变薄与随访时的注意力冲动有关。结果表明，青春期使用大麻与神经发育的改变有关，特别是在富含大麻素1受体的皮质中，并且在青春期中后期经历了最大的年龄相关厚度变化。这项队列研究探讨了在青少年纵向样本中，磁共振成像评估的大脑皮质厚度发育与大麻使用相关的程度。
To what extent is cannabis use associated with magnetic resonance imaging–measured cerebral cortical thickness development during adolescence? In this cohort study, linear mixed-effects model analysis using 1598 magnetic resonance images from 799 participants revealed that cannabis use was associated with accelerated age-related cortical thinning from 14 to 19 years of age in predominantly prefrontal regions. The spatial pattern of cannabis-related cortical thinning was significantly associated with a positron emission tomography–assessed map of cannabinoid 1 receptor availability. Results suggest that cannabis use during middle to late adolescence may be associated with altered cerebral cortical development, particularly in regions rich in cannabinoid 1 receptors. Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties between cannabis use and adolescent brain development in humans. To examine the degree to which magnetic resonance (MR) imaging–assessed cerebral cortical thickness development is associated with cannabis use in a longitudinal sample of adolescents. Data were obtained from the community-based IMAGEN cohort study, conducted across 8 European sites. Baseline data used in the present study were acquired from March 1, 2008, to December 31, 2011, and follow-up data were acquired from January 1, 2013, to December 31, 2016. A total of 799 IMAGEN participants were identified who reported being cannabis naive at study baseline and had behavioral and neuroimaging data available at baseline and 5-year follow-up. Statistical analysis was performed from October 1, 2019, to August 31, 2020. Cannabis use was assessed at baseline and 5-year follow-up with the European School Survey Project on Alcohol and Other Drugs. Anatomical MR images were acquired with a 3-dimensional T1-weighted magnetization prepared gradient echo sequence. Quality-controlled native MR images were processed through the CIVET pipeline, version 2.1.0. The study evaluated 1598 MR images from 799 participants (450 female participants [56.3%]; mean [SD] age, 14.4 [0.4] years at baseline and 19.0 [0.7] years at follow-up). At 5-year follow-up, cannabis use (from 0 to >40 uses) was negatively associated with thickness in left prefrontal (peak: t785 = –4.87, cluster size = 1558 vertices; P = 1.10 × 10−6, random field theory cluster corrected) and right prefrontal (peak: t785 = –4.27, cluster size = 1551 vertices; P = 2.81 × 10−5, random field theory cluster corrected) cortices. There were no significant associations between lifetime cannabis use at 5-year follow-up and baseline cortical thickness, suggesting that the observed neuroanatomical differences did not precede initiation of cannabis use. Longitudinal analysis revealed that age-related cortical thinning was qualified by cannabis use in a dose-dependent fashion such that greater use, from baseline to follow-up, was associated with increased thinning in left prefrontal (peak: t815.27 = –4.24, cluster size = 3643 vertices; P = 2.28 × 10−8, random field theory cluster corrected) and right prefrontal (peak: t813.30 = –4.71, cluster size = 2675 vertices; P = 3.72 × 10−8, random field theory cluster corrected) cortices. The spatial pattern of cannabis-related thinning was associated with age-related thinning in this sample (r = 0.540; P < .001), and a positron emission tomography–assessed cannabinoid 1 receptor–binding map derived from a separate sample of participants (r = −0.189; P < .001). Analysis revealed that thinning in right prefrontal cortices, from baseline to follow-up, was associated with attentional impulsiveness at follow-up. Results suggest that cannabis use during adolescence is associated with altered neurodevelopment, particularly in cortices rich in cannabinoid 1 receptors and undergoing the greatest age-related thickness change in middle to late adolescence. This cohort study examines the degree to which magnetic resonance imaging–assessed cerebral cortical thickness development is associated with cannabis use in a longitudinal sample of adolescents.
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作者：
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