Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients.
Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients.
复制标题
DOI：
10.1016/j.jpain.2011.04.008
复制
发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Dougherty PM
中科院分区：
文献类型：
--
作者：
Boyette-Davis JA;Cata JP;Zhang H;Driver LC;Wendelschafer-Crabb G;Kennedy WR;Dougherty PM
许多一线化疗药物产生强烈的神经病变作为剂量限制性副作用;然而，化疗相关的感觉障碍和疼痛的持续性尚未得到充分记录。我们以前研究了硼替佐米引起的疼痛的性质，现在试图确定这种疼痛的持续性质。26名对照受试者和11名先前接受过硼替佐米治疗并正在经历持续疼痛的患者同意重复进行定量感觉测试。还对患者获得的活检组织进行了皮肤神经支配的初步免疫组织化学研究。患者的心理物理测试显示持续变化，包括疼痛区域的皮肤温度降低、触摸和锐度检测减少、钉板完成时间增加以及对皮肤加热的敏感性降低。此外，尽管吗啡等效日剂量相似，但患者报告称，通过使用视觉模拟量表和疼痛描述符捕获的疼痛强度在复检期间未发生变化。患者皮肤活检显示表皮神经纤维和触觉小体密度显著降低。这些结果表明慢性硼替佐米诱导的化学神经病患者Aβ、Aδ和C纤维存在持续和严重的损伤。此外，这项研究报告了表皮神经纤维和迈斯纳小体的损失。这篇文章的结果表明，持续性，疼痛的周围神经病变的患者治疗硼替佐米。飞行员数据表明，神经纤维支配的疼痛区域的损失。这是第一篇文章，以解决持久性，和潜在的影响因素，硼替佐米化学神经病。
Many frontline chemotherapeutic agents produce robust neuropathy as a dose-limiting side effect; however, the persistence of chemotherapy-related sensory disturbances and pain are not well-documented. We have previously investigated the qualities of bortezomib-induced pain, and now seek to determine the ongoing nature of this pain. Twenty-six control subjects and eleven patients who had previously been treated with bortezomib and who were experiencing ongoing pain consented to recurring quantitative sensory testing. A pilot immunohistochemistry study of skin innervation was also performed on patient obtained biopsies. Psychophysical testing in patients revealed persistent changes including decreased skin temperature in the area of pain, diminished touch and sharpness detection, increased pegboard completion times, and decreased sensitivity to skin heating. Additionally, the intensity of pain, as captured by the use of a visual analog scale and pain descriptors, was reported by patients to be unchanged during the retest despite similar morphine equivalent daily doses. The patient skin biopsies displayed a marked decrease in the density of epidermal nerve fibers and Meissner’s corpuscles. These results signify a persistent and severe impairment of Aβ, Aδ, and C fibers in patients with chronic bortezomib-induced chemoneuropathy. Further, this study reports a loss of both epidermal nerve fibers and Meissner’s corpuscles. The results of this article indicate a persistent, painful peripheral neuropathy in patients treated with bortezomib. Pilot data indicates a loss of nerve fibers innervating the area of pain. This is the first paper to address the persistence, and potential contributing factors, of bortezomib chemoneuropathy.
登录
查看更多内容
影响因子：
7.4
作者：
Ledeboer, A;Sloane, EM;Watkins, LR
通讯作者：
Watkins, LR
影响因子：
2.9
作者：
Cata, Juan P.;Weng, Han-Rong;Dougherty, Patrick M.
通讯作者：
Dougherty, Patrick M.
影响因子：
3.3
作者：
Conti, G;De Pol, A;Scarlato, G
通讯作者：
Scarlato, G
影响因子：
2.4
作者：
Glasmacher, A;von Lilienfeld-Toal, M
通讯作者：
von Lilienfeld-Toal, M
影响因子：
9.9
作者：
Lisak, RP;Bealmear, B;Skoff, A
通讯作者：
Skoff, A