Use of high-frequency repetitive transcranial magnetic stimulation to probe the neural circuitry of food choice in anorexia nervosa: A proof-of-concept study.
Use of high-frequency repetitive transcranial magnetic stimulation to probe the neural circuitry of food choice in anorexia nervosa: A proof-of-concept study.
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DOI：
10.1002/eat.23597
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Attia E
中科院分区：
文献类型：
--
作者：
Muratore AF;Bershad M;Steinglass JE;Foerde KE;Gianini L;Broft A;Attia E
重复经颅磁刺激 (rTMS) 用于调节神经系统，并为有关神经性厌食症 (AN) 机制的假设提供实验测试的机会。本初步研究调查了对右侧背外侧前额叶皮层 (DLPFC) 区域进行高频重复经颅磁刺激 (HF-rTMS) 是否可能与成年 AN 住院患者食物选择的变化有关。 10 名女性接受了一次假手术和一次针对右侧 DLPFC 的 HF-rTMS 治疗，同时完成了计算机化的食物选择任务。与假手术相比，HF-rTMS 与食物评级和食物选择的变化相关：住院患者在接受 HF-rTMS 时，对低脂肪和高脂肪食物的健康评级较高，并且选择的高脂肪食物比例明显高于中性评级的参考项目。研究结果表明，对右侧 DLPFC 进行 HF-rTMS 与 AN 住院患者的食物选择任务中避免脂肪的减少相关，并为该区域和相关神经回路可能构成限制性食物选择的可能性提供了额外的支持。需要使用 rTMS 来实验测试神经机制的研究，以阐明 AN 的基础并支持新治疗靶点的开发。
Repetitive transcranial magnetic stimulation (rTMS) is used to modulate neural systems and provides the opportunity for experimental tests of hypotheses regarding mechanisms underlying anorexia nervosa (AN). The present pilot study has investigated whether high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to a region of the right dorsolateral prefrontal cortex (DLPFC) might be associated with change in food selection among adult inpatients with AN. Ten women received one session of sham and one session of HF-rTMS targeting the right DLPFC while completing a computerized Food Choice Task. Compared to sham, HF-rTMS was associated with changes in food ratings and food choice: inpatients reported higher healthiness ratings of low- and high-fat foods and selected a significantly greater proportion of high-fat foods over a neutrally rated reference item while receiving HF-rTMS. Findings suggest that HF-rTMS to the right DLPFC was associated with a reduction of fat avoidance on a food choice task among inpatients with AN and provide additional support for the possibility that this region, and related neural circuits, may underlie restrictive food choice. Research using rTMS to experimentally test neural mechanisms is needed to elucidate the underpinnings of AN and supports the development of novel treatment targets.
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影响因子：
7.1
作者：
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