Association of circulating calciprotein particle levels with skeletal muscle mass and strength in middle-aged and older adults
Association of circulating calciprotein particle levels with skeletal muscle mass and strength in middle-aged and older adults
复制标题
中老年人循环钙蛋白颗粒水平与骨骼肌质量和力量的关系
DOI：
10.1038/s41440-022-00870-y
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发表时间：
2022
影响因子：
5.4
通讯作者：
Maeda Seiji
中科院分区：
文献类型：
--
作者：
Yoshioka Masaki;Kosaki Keisei;Matsui Masahiro;Okabe Naoya;Saito Chie;Yamagata Kunihiro;Kuro-O Makoto;Maeda Seiji
钙蛋白颗粒（Calciprotein particles，CPPs）是由磷酸钙和胎球蛋白A组成的微小矿物质蛋白质聚集体。最近的研究表明，CPP可能有助于慢性炎症和动脉硬化的发病机制。据报道，骨骼肌质量和力量的减少独立地导致血清磷酸盐水平的升高。这一发现表明，骨骼肌质量和强度的降低可以内源性地诱导循环CPP水平的增加。因此，我们研究了中老年人循环CPP水平与骨骼肌质量和强度之间的潜在关联。182名中年和老年人（年龄，46-83岁）被纳入这项横断面研究（UMIN 000034741）。使用凝胶过滤法测量循环CPP水平。采用四极八点触觉电极系统，使用多频生物电阻抗分析评估了肩胛骨骨骼肌质量。骨骼肌质量指数是根据骨骼肌质量和身高计算的。握力和膝关节伸展强度被用作骨骼肌力量的测量。骨骼肌质量指数与循环CPP水平呈负相关（r=-0.31;P< 0.05）。在调整潜在协变量后，这种关联仍然显著（β=-0.34;P< 0.05）。相反，骨骼肌力量，代表的握力和膝关节伸展力量，是没有显着相关的循环CPP水平。在中年和老年人中，较低的骨骼肌质量指数与较高的循环CPP水平独立相关。目前的结果表明，保持骨骼肌质量可以防止循环CPP水平的增加。
Calciprotein particles (CPPs) are tiny mineral–protein aggregates consisting of calcium-phosphate and fetuin-A. Recent studies have suggested that CPPs may contribute to the pathogenesis of chronic inflammation and arteriosclerosis. Reduced skeletal muscle mass and strength reportedly contribute independently to increased serum phosphate levels. This finding suggests that reduced skeletal muscle mass and strength can endogenously induce an increase in circulating CPP levels. Therefore, we investigated the potential association between circulating CPP levels and skeletal muscle mass and strength in middle-aged and older adults. One hundred eighty-two middle-aged and older adults (age, 46–83 years) were included in this cross-sectional study (UMIN000034741). Circulating CPP levels were measured using the gel filtration method. Appendicular skeletal muscle mass was assessed using multifrequency bioelectrical impedance analysis with a tetrapolar eight-point tactile electrode system. The skeletal muscle mass index was calculated from appendicular skeletal muscle mass and height. Handgrip and knee extension strengths were used as measures of skeletal muscle strength. The skeletal muscle mass index was negatively correlated with circulating CPP levels (r= −0.31;P< 0.05). This association remained significant after adjustment for potential covariates (β= −0.34;P< 0.05). In contrast, skeletal muscle strength, represented by handgrip strength and knee extension strength, was not significantly associated with circulating CPP levels. In middle-aged and older adults, a lower skeletal muscle mass index was independently associated with higher circulating CPP levels. The present results suggest that maintaining skeletal muscle mass may prevent an increase in circulating CPP levels.
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影响因子：
4.9
作者：
Bozic, Milica;Panizo, Sara;Valdivielso, Jose M.
通讯作者：
Valdivielso, Jose M.
高磷/无锌饮食会加重代谢综合征大鼠模型的高血压和心脏功能障碍。
DOI：
10.1016/j.carpath.2013.06.004
发表时间：
2014
期刊：
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
影响因子：
--
作者：
Yuka Suzuki;S. Mitsushima;A. Kato;Takanori Yamaguchi;S. Ichihara
通讯作者：
S. Ichihara
影响因子：
18.2
作者：
Hu MC;Shiizaki K;Kuro-o M;Moe OW
通讯作者：
Moe OW
影响因子：
5.3
作者：
Gatate, Yodo;Nakano, Shintaro;Kuro-o, Makoto
通讯作者：
Kuro-o, Makoto
DOI：
--
发表时间：
2001
期刊：
影响因子：
--
作者：
P. Rogerson
通讯作者：
P. Rogerson