Change in number and activation of androgen receptor-immunoreactive cells in the medial amygdala in response to chemosensory input.
Change in number and activation of androgen receptor-immunoreactive cells in the medial amygdala in response to chemosensory input.
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DOI：
10.1016/j.neuroscience.2011.05.056
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发表时间：
2011-09-08
期刊：
影响因子：
3.3
通讯作者：
Meredith, M.
中科院分区：
文献类型：
--
作者：
Blake, C. B.;Meredith, M.
在许多物种中，社会行为依赖于化学感觉和荷尔蒙线索的整合。许多化学感觉刺激是由犁鼻器官检测到的，该器官投射到包含类固醇受体的许多区域，包括杏仁内侧核。在雄性仓鼠中，已知的是，睾丸激素在化学感觉刺激的反应下急剧增加；并可以通过杏仁内侧核的直接作用促进性行为。同种刺激激活杏仁内侧前核(MEA)和后核(MEP)，而异种刺激只激活MEA。不同社会意义的化学感觉刺激分别激活MEA和MEP的背侧和腹侧亚区。因此，类固醇可能通过不同的化学感觉刺激而不同地促进杏仁内侧核的刺激。我们使用Fos表达来检测异种和同种刺激对正常雄性仓鼠和用睾酮(T)替代的去势雄性仓鼠杏仁内侧核雄激素受体(AR)细胞的激活。AR免疫反应阳性(-ir)细胞的数量在完整雄性中与对照组和刺激之间有显著差异，但在T替代去势中没有明显差异。FOS的激活在所有动物中都是相似的。这一结果与完整动物体内AR-ir细胞数量的变化是一致的，这是由于化学信号导致睾丸激素的急剧增加。
In many species social behaviors are dependent on integration of chemosensory and hormonal cues. Many chemosensory stimuli are detected by the vomeronasal organ, which projects to many regions that contain steroid receptors, including the medial amygdala. In male hamsters, testosterone is known to acutely increase in response to chemosensory stimulation; and can facilitate sexual behavior by direct action within the medial amygdala. Conspecific stimuli activate the anterior (MeA) and posterior (MeP) medial amygdala, while heterospecific stimuli activate only MeA. Chemosensory stimuli with different social significance differentially activate the dorsal and ventral subdivisions of MeA and MeP. Therefore, it is likely that steroids differentially facilitate stimulation of the medial amygdala by various chemosensory stimuli. We used Fos expression to examine activation of androgen receptor (AR)-containing cells in the medial amygdala by heterospecific and conspecific stimuli in intact male hamsters and castrated males with testosterone (T)-replacement. The number of AR-immunoreactive (-ir) cells was significantly different from control and between stimuli in intact males, but not in T-replaced castrates. Fos activation was similar in all animals. The results are consistent with a change in number of AR-ir cells in intact animals due to acute increases in testosterone caused by chemosignals.
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影响因子：
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DOI：
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发表时间：
1996-07-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
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作者：
Handa, RJ;Kerr, JE;Hejna, G
通讯作者：
Hejna, G