Abdominal Adipose Tissue Distribution and Metabolic Risk
Abdominal Adipose Tissue Distribution and Metabolic Risk
复制标题
腹部脂肪组织分布和代谢风险
DOI：
10.2165/00007256-200333100-00001
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发表时间：
2003
期刊：
影响因子：
9.8
通讯作者：
R. Ross
中科院分区：
文献类型：
--
作者：
Suzy L. Wong;I. Janssen;R. Ross
现在已经确定，腰围仍然是疾病和代谢风险的重要预测指标，独立于体重指数测量的肥胖。这些观察结果得到了大量证据的加强，这些证据表明，通过成像方式测量的腹部肥胖与许多代谢危险因素的发病机制有关。然而，腹部皮下或内脏脂肪组织（AT）在多大程度上独立促成了腹部肥胖与代谢风险之间的关联，这仍然是一个相当多的研究课题。文献中的差异可能部分由方法学问题来解释，因为目前对于内脏或腹部皮下AT没有公认的定义。因此，在代谢和描述性研究中如何最好地测量这些储库存在困惑。此外，尽管许多研究将腹部AT库与代谢危险因素联系起来，但潜在的机制仍不清楚。本综述的主要目的是研究内脏和腹部皮下AT对肥胖相关健康风险病因学的独立贡献。我们首先考虑具体的方法学问题，关于目前腹部AT的分类，通过成像方法测量。必要时，我们提供原始数据，以加强在文献中没有适当解决的重要概念。最后，我们考虑了可能将腹部肥胖和代谢风险联系起来的机制。
It is now established that waist circumference remains a significant predictor of disease and metabolic risk independent of obesity measured by body mass index. These observations are reinforced by a large body of evidence implicating abdominal obesity measured by imaging modalities in the pathogenesis of numerous metabolic risk factors. However, the extent to which abdominal subcutaneous or visceral adipose tissue (AT) independently contribute to the established association between abdominal obesity and metabolic risk remains a subject of considerable research. Discrepancies in the literature may be partially explained by methodological issues, as currently there is no accepted definition for either visceral or abdominal subcutaneous AT. Accordingly, there is confusion concerning how best to measure these depots in metabolic and descriptive studies. Further, despite numerous studies linking abdominal AT depots with metabolic risk factors, the underlying mechanisms remain unclear.The primary purpose of this review is to examine the independent contribution of visceral and abdominal subcutaneous AT to the aetiology of obesity-related health risk. We begin by considering specific methodological issues with respect to the current classification of abdominal AT as measured by imaging methods. When necessary, we present original data to reinforce important concepts not suitably addressed in the literature. We conclude with a consideration of proposed mechanisms that may link abdominal adiposity and metabolic risk.
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患有 NIDDM 的胰岛素敏感和胰岛素抵抗黑人男性的肝脏脂肪、血清甘油三酯和内脏脂肪组织。
DOI：
--
发表时间：
1995
期刊：
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Banerji,MA;Buckley,MC;Chaiken,RL;Gordon,D;Lebovitz,HE;Kral,JG
通讯作者：
Kral,JG
DOI：
10.1210/jcem.86.11.7992
发表时间：
2001-11
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Annaswamy Raji;E. Seely;R. Arky;D. Simonson
通讯作者：
Annaswamy Raji;E. Seely;R. Arky;D. Simonson
影响因子：
15.9
作者：
FRIED, SK;RUSSELL, CD;BROLIN, RE
通讯作者：
BROLIN, RE
DOI：
10.1152/ajpendo.2001.280.6.e1000
发表时间：
2001-06-01
影响因子：
5.1
作者：
Basu, A;Basu, R;Jensen, MD
通讯作者：
Jensen, MD
瘦素对正常大鼠胰岛素敏感性的影响。
DOI：
10.1210/endo.138.8.5327
发表时间：
1997
期刊：
Endocrinology.
影响因子：
--
作者：
Sivitz,WI;Walsh,SA;Morgan,DA;Thomas,MJ;Haynes,WG
通讯作者：
Haynes,WG