TIM-1 and TIM-3 proteins in immune regulation.

TIM-1 and TIM-3 proteins in immune regulation.
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DOI:
10.1016/j.cyto.2008.06.013
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发表时间:
2008-10
期刊:
影响因子:
3.8
通讯作者:
Kane, Lawrence P.
Kane, Lawrence P.
中科院分区:
医学3区
文献类型:
--
作者:
Su, Ee Wern;Lin, Jean Y.;Kane, Lawrence P.

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在过去的几年中,人们对 TIM(T 细胞免疫球蛋白和粘蛋白结构域)家族蛋白在调节免疫反应中的作用越来越感兴趣。不管顾名思义,这个家族的蛋白质的功能比仅在 T 细胞上更广泛,正如我们将在这篇综述中讨论的那样。因此,我们建议将TIM的定义调整为“跨膜免疫球蛋白和粘蛋白”。
Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss in this review. We therefore propose that the definition of TIM be adjusted to “transmembrane immunoglobulin and mucin.”
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