Calcium as a signal integrator in developing epithelial tissues.
Calcium as a signal integrator in developing epithelial tissues.
复制标题
DOI：
10.1088/1478-3975/aabb18
复制
发表时间：
2018-05-16
期刊：
影响因子：
2
通讯作者：
Zartman JJ
中科院分区：
文献类型：
--
作者：
Brodskiy PA;Zartman JJ
Decoding how tissue properties emerge across multiple spatial and temporal scales from the integration of local signals is a grand challenge in quantitative biology. For example, the collective behavior of epithelial cells is critical for shaping developing embryos. Understanding how epithelial cells interpret a diverse range of local signals to coordinate tissue-level processes requires a systems-level understanding of development. Integration of multiple signaling pathways that specify cell signaling information requires second messengers such as calcium ions. Increasingly, specific roles have been uncovered for calcium signaling throughout development. Calcium signaling regulates many processes including division, migration, death, and differentiation. However, the pleiotropic and ubiquitous nature of calcium signaling implies that many additional functions remain to be discovered. Here we review a selection of recent studies to highlight important insights into how multiple signals are transduced by calcium transients in developing epithelial tissues. Quantitative imaging and computational modeling have provided important insights into how calcium signaling integration occurs. Reverse-engineering the conserved features of signal integration mediated by calcium signaling will enable novel approaches in regenerative medicine and synthetic control of morphogenesis.
登录
查看更多内容
DOI：
10.1083/jcb.201211039
发表时间：
2013-07-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Antunes M;Pereira T;Cordeiro JV;Almeida L;Jacinto A
通讯作者：
Jacinto A
影响因子：
4
作者：
Berridge, Michael J.
通讯作者：
Berridge, Michael J.
影响因子：
4.6
作者：
Aegerter-Wilmsen, Tinri;Heimlicher, Maria B.;Basler, Konrad
通讯作者：
Basler, Konrad
影响因子：
4.3
作者：
Bazzazi H;Popel AS
通讯作者：
Popel AS
影响因子：
3.9
作者：
Berridge, MJ
通讯作者：
Berridge, MJ