Pulmonary Sequelae at 4 Months After COVID-19 Infection: A Single-Centre Experience of a COVID Follow-Up Service.
Pulmonary Sequelae at 4 Months After COVID-19 Infection: A Single-Centre Experience of a COVID Follow-Up Service.
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DOI：
10.1007/s12325-021-01833-4
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发表时间：
2021-08
影响因子：
3.8
通讯作者：
Chaudhuri N
中科院分区：
文献类型：
--
作者：
Robey RC;Kemp K;Hayton P;Mudawi D;Wang R;Greaves M;Yioe V;Rivera-Ortega P;Avram C;Chaudhuri N
截至 COVID-19 大流行第一年末，已知幸存者人数已超过 7800 万。 COVID-19 的长期肺部后遗症仍不清楚。我们对新冠肺炎后随访服务进行了回顾性分析，以估计住院新冠幸存者持续性肺部发病率的负担。共有221名患者接受随访：44名重症监护病房（ICU）患者和177名病房患者。根据英国胸科学会指南，计划进行进一步的调查：针对所有 ICU 患者 (n = 44) 以及 177 名病房患者中的 38 名患者 (21%)，这些患者在首次 8 周随访时出现持续症状和/或 CXR 影像学变化。在以病房为基础的队列中，与持续症状有统计显着关联的是曾经或现在吸烟者、既往患有糖尿病以及住院时间较长。在需要进一步检查的患者中，出院后平均 15 周的肺功能测试 (PFT；n = 67) 显示 79% 的患者至少有一项 PFT 参数异常（相当于整个队列的 24%）。最常见的异常是一氧化碳扩散能力 (TLCO) 异常，在 ICU 队列中最高（ICU 为 64%，非 ICU 为 38%）。 TLCO 与整个患者组的住院时间和最大吸入 FiO2 呈负相关。在 ICU 患者中，TLCO 与最大吸入气道正压呈负相关。出院后平均 18 周的计算机断层扫描 (n = 72) 显示，44% 的患者存在持续毛玻璃混浊，21% 的患者存在纤维化（相当于整个队列的 7%）。我们的数据进一步证明，部分新冠肺炎幸存者会出现肺部后遗症，这为了解可能成为重大慢性全球健康问题的问题提供了一些见解。在线版本包含可在 10.1007/s12325-021-01833-4 获取的补充材料。
At the end of the first year of the COVID-19 pandemic, more than 78 million known survivors were recorded. The long-term pulmonary sequelae of COVID-19 remain unknown. We performed a retrospective analysis of a post-COVID follow-up service to estimate the burden of persistent pulmonary morbidity in hospitalised COVID survivors. A total of 221 patients were followed-up: 44 intensive care unit (ICU) and 177 ward patients. Further investigations were planned as per British Thoracic Society Guidelines: For all ICU patients (n = 44) and for 38 of 177 (21%) ward-based patients who had persistent symptoms and/or persistent radiographic changes on CXR at their initial 8-week follow-up visit. In the ward-based cohort, statistically significant associations with persistent symptoms were being an ex- or current smoker, having pre-existing diabetes, and having a longer length of stay. In patients requiring further investigations, pulmonary function tests (PFTs; n = 67) at an average of 15 weeks post-discharge showed abnormalities in at least one PFT parameter in 79% (equating to 24% of the entire cohort). The most common abnormality was an abnormal diffusion capacity of carbon monoxide (TLCO), highest in the ICU cohort (64% ICU vs. 38% non-ICU). TLCO correlated negatively with length of stay and with maximum inspired FiO2 in the patient group as a whole. In ICU patients, TLCO correlated negatively with maximum inspired positive airway pressure. Computed tomography scans (n = 72) at an average of 18 weeks post-discharge showed evidence of persistent ground glass opacities in 44% and fibrosis in 21% (equating to 7% of the entire cohort). Our data add to the growing evidence that there will be pulmonary sequelae in a proportion of COVID survivors, providing some insight into what may become a significant chronic global health problem. The online version contains supplementary material available at 10.1007/s12325-021-01833-4.
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影响因子：
3
作者：
Liu, Kai;Zhang, Weitong;Chen, Ying
通讯作者：
Chen, Ying
DOI：
10.4103/ijri.ijri_469_16
发表时间：
2017-07
期刊：
The Indian journal of radiology & imaging
影响因子：
--
作者：
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影响因子：
4.3
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影响因子：
5.8
作者：
Huang, Yiying;Tan, Cuiyan;Liu, Jing
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影响因子：
9.6
作者：
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