Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives.
Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives.
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DOI：
10.1002/hep.28709
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发表时间：
2017-01
期刊：
影响因子：
13.5
通讯作者：
Trauner, Michael
中科院分区：
文献类型：
--
作者：
Arab, Juan P.;Karpen, Saul J.;Dawson, Paul A.;Arrese, Marco;Trauner, Michael
非酒精性脂肪性肝病（NAFLD）是一个新兴的健康问题，是肝脏和心脏代谢死亡的重要危险因素。这种疾病及其侵袭性非酒精性脂肪性肝炎（NASH）的患病率迅速增加，需要新的治疗方法来预防疾病进展为晚期纤维化或肝硬化和癌症。近年来，胆汁酸作为一种相关的信号分子出现在肝脏和肝外组织中，调节脂质和碳水化合物代谢途径以及能量稳态。激活或调节胆汁酸受体，如法尼索酮X受体和TGR5，以及转运体，如回肠根尖钠依赖性胆汁酸转运体，似乎在多个水平上影响胰岛素敏感性和NAFLD/NASH发病机制，这些方法有望成为新的治疗方法。在本综述中，我们总结了胆汁酸与NAFLD之间关系的现有数据，以及针对胆汁酸相关途径的治疗潜力，以解决这一日益增长的世界性疾病。(肝脏病学2017;65:350公/ 362)
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing prevalence of this disease and of its aggressive form nonalcoholic steatohepatitis (NASH) will require novel therapeutic approaches to prevent disease progression to advanced fibrosis or cirrhosis and cancer. In recent years, bile acids have emerged as relevant signaling molecules that act at both hepatic and extrahepatic tissues to regulate lipid and carbohydrate metabolic pathways as well as energy homeostasis. Activation or modulation of bile acid receptors, such as the farnesoid X receptor and TGR5, and transporters, such as the ileal apical sodium‐dependent bile acid transporter, appear to affect both insulin sensitivity and NAFLD/NASH pathogenesis at multiple levels, and these approaches hold promise as novel therapies. In the present review, we summarize current available data on the relationships of bile acids to NAFLD and the potential for therapeutically targeting bile‐acid‐related pathways to address this growing world‐wide disease. (Hepatology 2017;65:350‐362)
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DOI：
10.1016/j.apsb.2015.01.001
发表时间：
2015-03
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
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通讯作者：
Dawson PA
影响因子：
25.7
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影响因子：
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