Limitations in bonding to dentin and experimental strategies to prevent bond degradation.
Limitations in bonding to dentin and experimental strategies to prevent bond degradation.
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DOI：
10.1177/0022034510391799
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发表时间：
2011-08
影响因子：
7.6
通讯作者：
Tay FR
中科院分区：
文献类型：
--
作者：
Liu Y;Tjäderhane L;Breschi L;Mazzoni A;Li N;Mao J;Pashley DH;Tay FR
树脂-牙本质粘合的有限耐用性严重影响了牙色修复体的使用寿命。键降解是通过基质金属蛋白酶 (MMP) 和半胱氨酸组织蛋白酶降解未达到最佳聚合的亲水性树脂成分以及富含水、树脂稀疏的胶原蛋白基质的水解而发生的。本综述检查了过去三年中不同研究小组为延长树脂-牙本质粘合寿命而开发的五种实验策略产生的数据。它们包括：（1）提高亲水性粘合剂的转化度和耐酯酶性； (2)使用广谱胶原分解酶抑制剂，包括接枝到甲基丙烯酸酯树脂单体上的新型抑制剂官能团来生产抗MMP粘合剂； (3) 使用交联剂来沉默 MMP 和组织蛋白酶的活性，从而不可逆地改变其催化/变构域的 3-D 结构； (4)乙醇与疏水性树脂湿粘合，以完全取代纤维外和纤维内胶原隔室中的水并固定胶原分解酶； (5)使用基质蛋白类似物对充满水的胶原基质进行仿生再矿化，以逐步用原纤维内和原纤维外磷灰石代替水，以排除外源性胶原分解酶并使内源性胶原分解酶石化。这些策略的结合应该能够克服目前牙本质粘接中遇到的关键进展障碍。
The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine cathepsins. This review examined data generated over the past three years on five experimental strategies developed by different research groups for extending the longevity of resin-dentin bonds. They include: (1) increasing the degree of conversion and esterase resistance of hydrophilic adhesives; (2) the use of broad-spectrum inhibitors of collagenolytic enzymes, including novel inhibitor functional groups grafted to methacrylate resins monomers to produce anti-MMP adhesives; (3) the use of cross-linking agents for silencing the activities of MMP and cathepsins that irreversibly alter the 3-D structures of their catalytic/allosteric domains; (4) ethanol wet-bonding with hydrophobic resins to completely replace water from the extrafibrillar and intrafibrillar collagen compartments and immobilize the collagenolytic enzymes; and (5) biomimetic remineralization of the water-filled collagen matrix using analogs of matrix proteins to progressively replace water with intrafibrillar and extrafibrillar apatites to exclude exogenous collagenolytic enzymes and fossilize endogenous collagenolytic enzymes. A combination of several of these strategies should result in overcoming the critical barriers to progress currently encountered in dentin bonding.
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影响因子：
3.3
作者：
Blackburn, Richard S.;Harvey, Anna;Russell, Stephen J.
通讯作者：
Russell, Stephen J.
影响因子：
7.6
作者：
Carrilho, M. R. O.;Carvalho, R. M.;Tjaderhane, L.
通讯作者：
Tjaderhane, L.
影响因子：
5
作者：
Carrilho, Marcela R.;Carvalho, Ricardo M.;Sousa, Ethan N.;Nicolau, Jose;Breschi, Lorenzo;Mazzoni, Annalisa;Tjaderhane, Leo;Tay, Franklin R.;Agee, Kelli;Pashley, David H.
通讯作者：
Pashley, David H.
影响因子：
3.9
作者：
Avci, R;Schweitzer, MH;Calvo, JO
通讯作者：
Calvo, JO
DOI：
10.1002/jbm.b.31295
发表时间：
2009-07
影响因子：
3.4
作者：
Carrilho, Marcela R.;Tay, Franklin R.;Donnelly, Adam M.;Agee, Kelli A.;Tjaederhane, Leo;Mazzoni, Annalisa;Breschi, Lorenzo;Foulger, Stephen;Pashley, David H.
通讯作者：
Pashley, David H.