Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray
Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray
复制标题
DNA微阵列研究抗菌肽Nal-P-113抑制牙龈卟啉单胞菌W83细菌生物膜形成的分子途径
DOI：
10.1186/s12866-017-0948-z
复制
发表时间：
2017-02
期刊：
影响因子：
4.2
通讯作者：
Pan Ya-ping
中科院分区：
文献类型：
--
作者：
Wang Hong-yan;Lin Li;Tan Li-si;Yu Hui-Yuan;Cheng Jya-Wei;Pan Ya-ping
背景
伤口相关感染对医疗专业人员而言仍是一项重大挑战。传统抗生素的一个弊端在于其无法穿透生物膜，而生物膜是细菌躲避抗菌作用的主要保护机制。此前，我们已……
（原文最后“we hav”表述不完整，推测可能是“we have” ，若有更完整准确内容，可进一步优化译文。）
BackgroundWound-related infection remains a major challenge for health professionals. One disadvantage in conventional antibiotics is their inability to penetrate biofilms, the main protective strategy for bacteria to evade irradiation. Previously, we have shown that synthetic antimicrobial peptides could inhibit bacterial biofilms formation.ResultsIn this study, we first delineated how Nal-P-113, a novel antimicrobial peptide, exerted its inhibitory effects on Porphyromonas gingivalis W83 biofilms formation at a low concentration. Secondly, we performed gene expression profiling and validated that Nal-P-113 at a low dose significantly down-regulated genes related to mobile and extrachromosomal element functions, transport and binding proteins in Porphyromonas gingivalis W83.ConclusionsThese findings suggest that Nal-P-113 at low dose is sufficient to inhibit the formation of biofilms although Porphyromonas gingivalis W83 may maintain its survival in the oral cavity. The newly discovered molecular pathways may add the knowledge of developing a new strategy to target bacterial infections in combination with current first-line treatment in periodontitis.
登录
查看更多内容
影响因子：
2.4
作者：
Wimley, William C.;Hristova, Kalina
通讯作者：
Hristova, Kalina
影响因子：
3.2
作者：
Nelson, KE;Fleischmann, RD;Fraser, CM
通讯作者：
Fraser, CM
影响因子：
3.1
作者：
KOLENBRANDER, PE;ANDERSEN, RN;GANESHKUMAR, N
通讯作者：
GANESHKUMAR, N
影响因子：
2.5
作者：
Sang, Yongming;Blecha, Frank
通讯作者：
Blecha, Frank
影响因子：
3.1
作者：
Overhage, Joerg;Campisano, Andrea;Hancock, Robert E. W.
通讯作者：
Hancock, Robert E. W.