Trends in clinical presentation of children with COVID-19: a systematic review of individual participant data.
Trends in clinical presentation of children with COVID-19: a systematic review of individual participant data.
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DOI：
10.1038/s41390-020-01161-3
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发表时间：
2022-03
影响因子：
3.6
通讯作者：
Michelow IC
中科院分区：
文献类型：
--
作者：
Christophers B;Gallo Marin B;Oliva R;Powell WT;Savage TJ;Michelow IC
对于患有新型冠状病毒病(新冠肺炎)的儿童，可获得的患者水平数据很少。因此，迫切需要更新系统的文献审查，分析个别儿童，而不是广泛年龄组的汇总数据。应用计算机检索6个数据库(MEDLINE、Scope us、Web of Science、CINAHL、Google Scholar、MedRxiv)，检索词为儿童、儿科、新冠肺炎、SARS-CoV-2，限定文章语言种类为2020-01-05-05。共识别了1,241条记录，其中仅收录了包含患者个人信息和新冠肺炎检测文件的唯一英文论文。这项对22项符合条件的研究的审查遵循了系统审查和个体参与者数据指南的荟萃分析的首选报告项目。来自五个国家的123名患者被确认。46%为女性。中位年龄为5岁(IQR=8)。出现症状时，62%有发热，32%有咳嗽，58%有单一症状，21%没有症状。胸部影像异常率为62%(65/105)，无症状儿童为76.9%(20/26)。少数儿童的血小板、C反应蛋白、乳酸脱氢酶和d-二聚体升高。这项独立参与者数据系统回顾的数据显示，大多数新冠肺炎儿童要么没有症状，要么只有一个非呼吸道症状。
There are sparse patient-level data available for children with novel coronavirus disease (COVID-19). Therefore, there is an urgent need for an updated systematic literature review that analyzes individual children rather than aggregated data in broad age groups. Six databases (MEDLINE, Scopus, Web of Science, CINAHL, Google Scholar, medRxiv) were searched for studies indexed from January 1 to May 15, 2020 with MeSH terms: children, pediatrics, COVID-19, SARS-CoV-2. 1241 records were identified, of which only unique papers in English with individual patient information and documented COVID-19 testing were included. This review of 22 eligible studies followed Preferred Reporting Items for Systematic Review and Meta-Analyses of individual participant data guidelines. 123 patients from five countries were identified. 46% were females. Median age was five years (IQR=8). At presentation, 62% had fever, 32% had cough, 58% had a single symptom and 21% were asymptomatic. Abnormal chest imaging was seen in 62% (65/105) of imaged and 76.9% (20/26) of asymptomatic children. A minority of children had elevated platelets, CRP, lactate dehydrogenase, and d-dimer. Data from this independent participant data systematic review revealed that the majority of children with COVID-19 presented with either no symptoms or a single, non-respiratory symptom.
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