Mechanics of Development.

Mechanics of Development.
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DOI:
10.1016/j.devcel.2020.11.025
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发表时间:
2021-01-25
期刊:
影响因子:
11.8
通讯作者:
Nelson CM
Nelson CM
中科院分区:
生物学1区
文献类型:
--
作者:
Goodwin K;Nelson CM

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从胚胎发生的最早阶段到复杂器官的构建和分化,机械力是发育的组成部分。成像和生物物理工具的进步使我们能够深入研究日益复杂的器官和生物体的发育机械生物学。在这里,我们专注于最近的工作,突出的多样性和重要性,在形态发生的机械影响。发育中的组织经历来自主动力的内在机械信号和组织机械特性的变化,以及外在机械信号,包括约束力和压缩力、压力和剪切力。最后,我们建议在这个迅速扩大的领域未来的工作有前途的途径。
Mechanical forces are integral to development, from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging and biophysical tools have allowed us to delve into the developmental mechanobiology of increasingly complex organs and organisms. Here, we focus on recent work that highlights the diversity and importance of mechanical influences during morphogenesis. Developing tissues experience intrinsic mechanical signals from active forces and changes to tissue mechanical properties, as well as extrinsic mechanical signals, including constraint and compression, pressure, and shear forces. Finally, we suggest promising avenues for future work in this rapidly expanding field.
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