Task-based functional connectivity in aging: How task and connectivity methodology affect discovery of age effects.
Task-based functional connectivity in aging: How task and connectivity methodology affect discovery of age effects.
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DOI：
10.1002/brb3.1954
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发表时间：
2021-01
影响因子：
3.1
通讯作者：
Stern Y
中科院分区：
文献类型：
--
作者：
Varangis E;Habeck CG;Stern Y
Past studies have found that healthy aging has a significant effect on the organization and function of networks in the human brain. Many of these studies have examined how functional connectivity during one task or at rest is affected by aging; however, few studies have systematically examined how the effect of age on functional connectivity may vary as a function of choice of in‐scanner task. The present study included healthy adults between the ages of 20 and 80 and examined a variety of metrics of functional connectivity during performance of 11 in‐scanner tasks, falling into 4 cognitive domains: vocabulary, processing speed, fluid reasoning, and episodic memory. Functional connectivity was assessed at three levels: average correlations within and between 10 networks, system segregation (sensorimotor vs. association networks), and whole‐brain graph theory metrics (global efficiency and modularity). Results showed that the effect of age on these metrics differed as a function of task-for example, age had a more consistent effect on functional connectivity metrics computed during fluid reasoning tasks; however, there was less of an effect of age on functional connectivity metrics computed during tasks of episodic memory. Further, some of these measures showed relationships with behavioral performance on the in‐scanner task, with different networks playing a role in the different cognitive domains. These findings suggest that while aging may be generally associated with reductions in within‐ and between‐network connectivity, system segregation, global efficiency, and modularity, the magnitude and presence of these effects varies by in‐scanner task. The present study examined the effects of task domain and age on functional connectivity computed during a set of 11 cognitive tasks. Results showed that task domain had a significant effect on the presence and magnitude of the effect of age on functional connectivity measures, and that age‐related connectivity differences were more readily observed during tasks of fluid reasoning, and less likely to be observed during memory tasks. These findings suggest that task choice has a significant effect on estimation of age‐related differences in neurocognitive functioning.
Past studies have found that healthy aging has a significant effect on the organization and function of networks in the human brain. Many of these studies have examined how functional connectivity during one task or at rest is affected by aging; however, few studies have systematically examined how the effect of age on functional connectivity may vary as a function of choice of in‐scanner task. The present study included healthy adults between the ages of 20 and 80 and examined a variety of metrics of functional connectivity during performance of 11 in‐scanner tasks, falling into 4 cognitive domains: vocabulary, processing speed, fluid reasoning, and episodic memory. Functional connectivity was assessed at three levels: average correlations within and between 10 networks, system segregation (sensorimotor vs. association networks), and whole‐brain graph theory metrics (global efficiency and modularity). Results showed that the effect of age on these metrics differed as a function of task—for example, age had a more consistent effect on functional connectivity metrics computed during fluid reasoning tasks; however, there was less of an effect of age on functional connectivity metrics computed during tasks of episodic memory. Further, some of these measures showed relationships with behavioral performance on the in‐scanner task, with different networks playing a role in the different cognitive domains. These findings suggest that while aging may be generally associated with reductions in within‐ and between‐network connectivity, system segregation, global efficiency, and modularity, the magnitude and presence of these effects varies by in‐scanner task. The present study examined the effects of task domain and age on functional connectivity computed during a set of 11 cognitive tasks. Results showed that task domain had a significant effect on the presence and magnitude of the effect of age on functional connectivity measures, and that age‐related connectivity differences were more readily observed during tasks of fluid reasoning, and less likely to be observed during memory tasks. These findings suggest that task choice has a significant effect on estimation of age‐related differences in neurocognitive functioning.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
额顶认知控制网络的年龄差异：对注意力分散的影响。
影响因子：
2.6
作者：
Campbell KL;Grady CL;Ng C;Hasher L
通讯作者：
Hasher L
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
2.7
作者：
Prakash, Ruchika Shaurya;Heo, Susie;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
4.8
作者：
Geerligs, Linda;Maurits, Natasha M.;Lorist, Monicque M.
通讯作者：
Lorist, Monicque M.