Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles.
Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles.
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DOI：
10.1016/j.plefa.2018.05.001
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Newman JW
中科院分区：
文献类型：
--
作者：
Agrawal K;Hassoun LA;Foolad N;Borkowski K;Pedersen TL;Sivamani RK;Newman JW
皮肤病会改变皮肤脂质介质代谢，如果皮肤分泌物含有这些变化的证据，它们可能构成有用的临床基质，相关受试者负担较低。皮肤病对皮脂介质的影响尚不清楚。本研究采用LC-MS/MS和GC-MS对患有和不患有静止性特应性皮炎（AD）的受试者的非病变双侧脸颊的皮脂氧化脂、内源性大麻素、鞘脂和脂肪酸进行定量分析。AD降低了C36 [NS]和[NdS]神经酰胺浓度。与雄性相比，雌性的氧脂醇和酮、饱和和单不饱和非酯化脂肪酸浓度增加，C42 [NS]和[NdS]神经酰胺浓度降低。此外，同时收集的汗液脂质介质谱是不同的，皮脂显示大多数目标浓度较高，但高极性脂质较少。因此，即使在静止受试者的非病变皮肤中，AD和性别似乎也会改变皮脂代谢。
Skin disease alters cutaneous lipid mediator metabolism, and if skin secretions contain evidence of these changes, they may constitute useful clinical matrices with low associated subject burden. The influences of skin diseases on sebum lipid mediators are understudied. Here, sebum oxylipins, endocannabinoids, sphingolipids, and fatty acids were quantified from the non-lesional bilateral cheeks of subjects with and without quiescent atopic dermatitis (AD) using LC-MS/MS and GC-MS. AD decreased C36 [NS] and [NdS] ceramide concentrations. Compared to males, females demonstrated increased concentrations of oxylipin alcohols and ketones, and saturated and monounsaturated non-esterified fatty acids, as well as decreased concentrations of C42 [NS] and [NdS] ceramides. Additionally, contemporaneously collected sweat lipid mediator profiles were distinct, with sebum showing higher concentrations of most targets, but fewer highly polar lipids. Therefore, AD and gender appear to alter sebum lipid metabolism even in non-lesional skin of quiescent subjects.
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影响因子：
2.9
作者：
Agrawal K;Waller JD;Pedersen TL;Newman JW
通讯作者：
Newman JW
影响因子：
2.7
作者：
Clarys, P;Barel, A
通讯作者：
Barel, A
影响因子：
6.5
作者：
IMOKAWA, G;ABE, A;HIDANO, A
通讯作者：
HIDANO, A
影响因子：
6.5
作者：
Iwata, C;Akimoto, N;Ito, A
通讯作者：
Ito, A
DOI：
10.4161/derm.1.3.8473
发表时间：
2009-01-01
期刊：
DERMATO-ENDOCRINOLOGY
影响因子：
--
作者：
Pappas, Apostolos;Johnsen, Stefanie;Eisinger, Magdalena
通讯作者：
Eisinger, Magdalena