Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.
Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.
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DOI：
10.1002/cne.24873
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发表时间：
2020-08
影响因子：
2.5
通讯作者：
Renna, Jordan M.
中科院分区：
文献类型：
--
作者：
Sondereker, Katelyn B.;Stabio, Maureen E.;Renna, Jordan M.
关键词：
黑视素神经节细胞自从20年前被发现以来就一直违反常规。在随后的几年中，出现了许多类型的这些固有光敏视网膜神经节细胞（ipRGC）。在小鼠视网膜中，目前已知有六种类型（M1-M6）的黑视素神经节细胞，每种都具有独特的形态、镶嵌、连接、生理学、投射和功能。虽然表达黑视蛋白的细胞通常与昼夜光诱导和瞳孔光反射等行为相关，但多种类型的表征已经证明其范围可能远远超出非成像视觉。事实上，研究已经表明，个别类型的黑视素神经节细胞有可能影响成像功能，如对比敏感度和颜色一致性。因此，本综述的目的是总结小鼠视网膜中六种已知类型的黑视素神经节细胞的形态和功能方面，并突出它们各自在非成像和成像视觉中的作用。虽然许多黑视素神经节细胞类型确实投射到成像大脑目标，但重要的是要注意，这只是确定它们对成像视觉影响的第一步。即便如此，视觉系统已经被规范地分为这两个功能领域，黑视素神经节细胞已经开始挑战它们之间的边界，提供互补而不是冗余的视觉信息的重叠。对这些神经节细胞光感受器的进一步研究无疑将继续说明黑视素神经节细胞在成像视觉中的作用不断扩大。
Melanopsin ganglion cells have defied convention since their discovery almost 20 years ago. In the years following, many types of these intrinsically photosensitive retinal ganglion cells (ipRGCs) have emerged. In the mouse retina, there are currently six known types (M1–M6) of melanopsin ganglion cells, each with unique morphology, mosaics, connections, physiology, projections, and functions. While melanopsin-expressing cells are usually associated with behaviors like circadian photoentrainment and the pupillary light reflex, the characterization of multiple types has demonstrated a reach that may extend far beyond non-image-forming vision. In fact, studies have shown that individual types of melanopsin ganglion cells have the potential to impact image-forming functions like contrast sensitivity and color opponency. Thus, the goal of this review is to summarize the morphological and functional aspects of the six known types of melanopsin ganglion cells in the mouse retina and to highlight their respective roles in non-image-forming and image-forming vision. Although many melanopsin ganglion cell types do project to image-forming brain targets, it is important to note that this is only the first step in determining their influence on image-forming vision. Even so, the visual system has canonically been divided into these two functional realms and melanopsin ganglion cells have begun to challenge the boundary between them, providing an overlap of visual information that is complementary rather than redundant. Further studies on these ganglion cell photoreceptors will no doubt continue to illustrate an ever-expanding role for melanopsin ganglion cells in image-forming vision.
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影响因子：
25
作者：
Altimus, Cara M.;Gueler, Ali D.;Alam, Nazia M.;Arman, A. Cyrus;Prusky, Glen T.;Sampath, Alapakkam P.;Hattar, Samer
通讯作者：
Hattar, Samer
影响因子：
9.8
作者：
Brown TM;Gias C;Hatori M;Keding SR;Semo M;Coffey PJ;Gigg J;Piggins HD;Panda S;Lucas RJ
通讯作者：
Lucas RJ
影响因子：
1.8
作者：
Barrionuevo PA;Cao D
通讯作者：
Cao D
DOI：
10.1073/pnas.0808312105
发表时间：
2008-12-16
影响因子：
11.1
作者：
Altimus, C. M.;Guler, A. D.;Hattar, S.
通讯作者：
Hattar, S.
影响因子：
64.8
作者：
Dacey, DM;Liao, HW;Gamlin, PD
通讯作者：
Gamlin, PD