Casual Associations and Shape Between Prepuberty Body Mass Index and Early Onset of Puberty: A Mendelian Randomization and Dose-Response Relationship Analysis.
Casual Associations and Shape Between Prepuberty Body Mass Index and Early Onset of Puberty: A Mendelian Randomization and Dose-Response Relationship Analysis.
复制标题
青春期前体重指数与青春期提前之间的因果关联和形状：孟德尔随机化和剂量反应关系分析
DOI：
10.3389/fendo.2022.853494
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Fang J;Yuan J;Zhang D;Liu W;Su P;Wan Y;Zhang Z;Tao F;Sun Y
关于青春期的开始是否与儿童体重指数有关，一直存在争议。目的探讨青春期前BMI与青春期早发之间的因果关系及其形态。方法由专业内分泌学家对997名儿童的乳腺发育和睾丸体积进行连续数年的年度评估。选择17个青春期和bmi相关的snp来计算多基因风险评分。采用两阶段最小二乘法评估和确认因果关系。使用限制性三次样条Cox回归分析青春期前BMI与青春期早发之间的剂量-反应关系。结果校正协变量后，青春期前BMI与女孩早期骨质疏松呈正相关（系数= 0.18,95% CI: 0.01, 0.29）。非线性模型显示青春期前BMI与早期骨质疏松风险呈倒u型关系（χ2 = 276.3, p < 0.001）。从青春期前BMI 15.70 kg/m2 （P25）迅速增加到20.75 kg/m2 (P85)，之后逐渐下降。与青春期前BMI的P25相比，早期儿童期BMI分类中25 - p50、50 - p75、75 - P85和≥P85百分位数的HRs （95% CI）分别为5.08（1.15,8.55）、4.48（1.02,7.74）、10.15（3.93,17.50）和8.43（1.91,13.71）。在男孩中，与P25的青春期前BMI相比，BMI在P25和P50之间的男孩青春期提前的风险增加（HR: 3.94, 95% CI: 1.44, 6.80）。结论青春期前BMI可能有助于识别早期肥胖的高危女孩，有助于制定针对儿童肥胖的预防和干预策略。研究结果强调了青春期前身体质量指数和青春期早发之间的非线性关系。
Background There is an ongoing controversial issue regarding whether onset of puberty is related to childhood BMI. Objectives This study aims at investigating the causal association and its shape between prepuberty BMI and early puberty onset. Methods Breast development and testicular volume were assessed annually from a population-based prospective cohort of 997 children for consecutive years by professional endocrinologists. Seventeen puberty- and BMI-related SNPs were selected to calculate the polygenic risk score. The two-stage least square method was used to assess and confirm causal effects. A dose–response association between prepuberty BMI and early puberty onset was conducted by using restricted cubic spline Cox regression. Results After adjusting for covariates, prepuberty BMI was positively associated with early thelarche among girls (coefficients = 0.18, 95% CI: 0.01, 0.29). A non-linear model suggested an inverted U-shaped relationship between prepuberty BMI and risk for early thelarche (χ2 = 276.3, p < 0.001). The risk for early thelarche increased rapidly from prepuberty BMI at 15.70 kg/m2 (P25) to 20.75 kg/m2 (P85) and gradually decreased afterward. Compared with the P25 of prepuberty BMI, the HRs (95% CI) for early thelarche were 5.08 (1.15, 8.55), 4.48 (1.02, 7.74), 10.15 (3.93, 17.50), and 8.43 (1.91, 13.71) for percentiles P25–P50, P50–P75, P75–P85, and ≥P85 of BMI categories, respectively. In boys, compared with the P25 of prepuberty BMI, boys with BMI between P25 and P50 showed an increased risk of early puberty (HR: 3.94, 95% CI: 1.44, 6.80). Conclusions Prepuberty BMI may serve the purpose of identifying the girls at higher risk of early thelarche, which could assist in the adaptation of prevention and intervention strategies targeting childhood obesity. The findings emphasize a non-linear correlation between prepuberty BMI and early puberty onset.
登录
查看更多内容
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
调查性早熟与肥胖之间的关系：中国上海的一项横断面研究
影响因子：
2.9
作者：
Chen C;Zhang Y;Sun W;Chen Y;Jiang Y;Song Y;Lin Q;Zhu L;Zhu Q;Wang X;Liu S;Jiang F
通讯作者：
Jiang F
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
5.8
作者：
Mouritsen, Annette;Aksglaede, Lise;Juul, Anders
通讯作者：
Juul, Anders
影响因子：
6.1
作者：
Busch, A. S.;Hollis, B.;Hagen, C. P.
通讯作者：
Hagen, C. P.