The role of hydrogen peroxide in environmental adaptation of oral microbial communities.
The role of hydrogen peroxide in environmental adaptation of oral microbial communities.
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DOI：
10.1155/2012/717843
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发表时间：
2012
影响因子：
--
通讯作者：
Kreth J
中科院分区：
文献类型：
--
作者：
Zhu L;Kreth J
口服链球菌能够产生生长抑制量的过氧化氢（H2O2）作为有氧代谢的副产物。最近的几项研究表明，产生的H2 O2不是简单的代谢副产物，而是在口腔细菌生物膜生态的多个方面发挥作用。首先，从细胞中释放DNA与血链球菌和戈登链球菌中H2O2的产生密切相关。细胞外DNA对于生物膜的形成和稳定是至关重要的，也可以作为口腔链球菌之间水平基因转移的来源。其次，由于H2O2的生长抑制性质，H2O2相容性物种与生产者相关联。因此，H2O2的产生可能有助于构建初始生物膜的发展。另一方面，口腔环境含有有效清除H2O2的唾液过氧化物酶。因此，生物膜固有的H2O2生产的影响可能是局部局限的。然而，考虑到80%的初始口腔生物膜成分是链球菌，H2O2对生物膜的发展和环境适应的影响可能在目前的研究中被低估。
Oral streptococci are able to produce growth-inhibiting amounts of hydrogen peroxide (H2O2) as byproduct of aerobic metabolism. Several recent studies showed that the produced H2O2 is not a simple byproduct of metabolism but functions in several aspects of oral bacterial biofilm ecology. First, the release of DNA from cells is closely associated to the production of H2O2 in Streptococcus sanguinis and Streptococcus gordonii. Extracellular DNA is crucial for biofilm development and stabilization and can also serve as source for horizontal gene transfer between oral streptococci. Second, due to the growth inhibiting nature of H2O2, H2O2 compatible species associate with the producers. H2O2 production therefore might help in structuring the initial biofilm development. On the other hand, the oral environment harbors salivary peroxidases that are potent in H2O2 scavenging. Therefore, the effects of biofilm intrinsic H2O2 production might be locally confined. However, taking into account that 80% of initial oral biofilm constituents are streptococci, the influence of H2O2 on biofilm development and environmental adaptation might be under appreciated in current research.
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影响因子：
3.2
作者：
Itzek, Andreas;Zheng, Lanyan;Kreth, Jens
通讯作者：
Kreth, Jens
影响因子：
3.2
作者：
Brown, Stacie A.;Whiteley, Marvin
通讯作者：
Whiteley, Marvin
影响因子：
3.2
作者：
Berg, Kari Helene;Ohnstad, Hilde Solheim;Havarstein, Leiv Sigve
通讯作者：
Havarstein, Leiv Sigve
影响因子：
3
作者：
Ihalin, R;Loimaranta, V;Tenovuo, J
通讯作者：
Tenovuo, J
DOI：
10.1016/j.meegid.2012.02.014
发表时间：
2012-07
期刊：
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
影响因子：
--
作者：
Boggs JM;South AH;Hughes AL
通讯作者：
Hughes AL