Meal frequency patterns determine the phase of mouse peripheral circadian clocks.
Meal frequency patterns determine the phase of mouse peripheral circadian clocks.
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DOI：
10.1038/srep00711
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发表时间：
2012
影响因子：
4.6
通讯作者：
Shibata, Shigenobu
中科院分区：
文献类型：
--
作者：
Kuroda, Hiroaki;Tahara, Yu;Saito, Keisuke;Ohnishi, Nobuaki;Kubo, Yuji;Seo, Yasuhiro;Otsuka, Makiko;Fuse, Yuta;Ohura, Yuki;Hirao, Akiko;Shibata, Shigenobu
哺乳动物的外周生物钟受到明暗和饮食周期的强烈影响。它们的生理功能是通过时钟基因表达模式使器官的相位同步来维持的。然而，人们对于外周生物钟如何适应每日多次进餐的时间知之甚少。在这里，我们研究了不规则饮食模式（在时间和数量方面）对其体内外周时钟的影响。我们发现，外周时钟的相位会因食物量和喂食时间点之间的间隔而改变，但只要间隔保持固定，就不受喂食频率的影响。此外，我们的结果表明，较晚的晚餐应分为两顿半晚餐，以减轻外周时钟相位不规则的影响。
Peripheral circadian clocks in mammals are strongly entrained by light-dark and eating cycles. Their physiological functions are maintained by the synchronization of the phase of organs via clock gene expression patterns. However, little is known about the adaptation of peripheral clocks to the timing of multiple daily meals. Here, we investigated the effect of irregular eating patterns, in terms of timing and volume, on their peripheral clocks in vivo. We found that the phase of the peripheral clocks was altered by the amount of food and the interval between feeding time points but was unaffected by the frequency of feeding, as long as the interval remained fixed. Moreover, our results suggest that a late dinner should be separated into 2 half-dinners in order to alleviate the effect of irregular phases of peripheral clocks.
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DOI：
10.1126/science.1171641
发表时间：
2009-05-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ramsey KM;Yoshino J;Brace CS;Abrassart D;Kobayashi Y;Marcheva B;Hong HK;Chong JL;Buhr ED;Lee C;Takahashi JS;Imai S;Bass J
通讯作者：
Bass J
影响因子：
1.2
作者：
Hsieh, Shiun Dong;Muto, Takashi;Arase, Yasuji
通讯作者：
Arase, Yasuji
影响因子：
13.9
作者：
Mohawk JA;Green CB;Takahashi JS
通讯作者：
Takahashi JS
对于适当的小鼠肝钟的夹带信号是必需的。
影响因子：
3.7
作者：
Hirao A;Tahara Y;Kimura I;Shibata S
通讯作者：
Shibata S
影响因子：
3.7
作者：
Luby MD;Hsu CT;Shuster SA;Gallardo CM;Mistlberger RE;King OD;Steele AD
通讯作者：
Steele AD