Lack of relationship between acoustic startle and cognitive variables in schizophrenia and control subjects.
Lack of relationship between acoustic startle and cognitive variables in schizophrenia and control subjects.
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DOI：
10.1016/j.psychres.2011.02.011
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发表时间：
2011-05-30
影响因子：
11.3
通讯作者：
Duncan, Erica
中科院分区：
文献类型：
--
作者：
Hasenkamp, Wendy;Kelley, Mary;Egan, Glenn;Green, Amanda;Wilcox, Lisette;Boshoven, William;Lewison, Barbara;Duncan, Erica
人们发现，精神分裂症患者的听觉惊吓指标，例如前脉冲抑制（PPI）和惊吓潜伏期受到损害，并且通常被认为与该疾病的认知缺陷有关。然而，关于惊吓变量和认知表现之间关系的研究结果却是模棱两可的。在这项研究中，我们检查了 107 名精神分裂症患者和 94 名健康对照者的惊吓测量（基线惊吓强度、潜伏期、习惯化和 PPI）和认知表现（使用本顿视觉保留测试、康纳连续表现测试、加州语言学习测试、手指敲击测试和威斯康星州卡片分类测试）之间的相关性。总体而言，在校正多重比较时，两个群体中的这些构建之间缺乏任何显着关系。这表明精神分裂症中惊吓措施的改变可能并不反映导致该疾病认知缺陷的信息处理要素。
Measures of acoustic startle such as prepulse inhibition (PPI) and startle latency have been found to be impaired in schizophrenia, and are commonly thought to be related to cognitive deficits in this disease. However, findings about the relationship between startle variables and cognitive performance have been equivocal. In this study, we examined correlations between startle measures (baseline startle magnitude, latency, habituation and PPI) and cognitive performance (using the Benton Visual Retention Test, Conner’s Continuous Performance Test, California Verbal Learning Test, Finger Tapping Test, and Wisconsin Card Sort Test) in 107 schizophrenia patients and 94 healthy controls. Overall, there was a lack of any significant relationship between these constructs in both populations when correcting for multiple comparisons. This suggests that alterations in startle measures seen in schizophrenia may not reflect elements of information processing that cause cognitive deficits in the disease.
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